Wikipedia Linking - Melanotan-II
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Bank - Melanotan-II
KEGG (Kyoto Encyclopedia of Genes and Genomes) - Melanotan-II
http://www.ncbi.nlm.nih.gov/ - Melanotan-II
Melanotan II was developed by researchers at the University of Arizona College of Medicine. Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH), this hormone provides a therapeutic tan with the ability to lower the risk of skin cancer, (MSH) also plays an important role in regulating sexual arousal in men and women. Melanotan II has the additional effect of decreasing body fat mass and is known to suppress the appetite. Melanotan II is a cyclic lactyam analog of alpha-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. Melanotan II is in a class of peptide hormones known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals.
Melonotan tanning peptide binds to melanocortin receptor and influence pigmentation, inflammation, energy, appetite and sexual function. Melanotan II has a small proactive amino acid structure that shows effect at the melonocortin 1, 3, 4 and 5 receptors. The central of Melanocortin system controls the food intake and weight of body. Usually, disruption of Melonocortin receptor (MCR) has been found in the cases of obesity. Melonocortins have also direct effect on adipocytes through lipid mobilization. Melanocortin peptides can be used to improve insulin sensitivity by stimulating fatty acid oxidation.