MELANOTAN-II

Synonyms. Melanotan-II; Melanotan II acetate; Ac-[Nle(4)Asp(5)D-Phe(7)Lys(10)]alpha-MSH- (4-10)-NH2; N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl- D-phenylalanyl-L-arginyl-L-tryptophyl-L- lysinamide cyclic (2-7)-peptide; 15-(2-Acetamidohexanoylamino)-9-benzyl-6-[3- (diaminomethylideneamino) propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14, 17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide;

MELANOTAN-II

 

PRODUCT IDENTIFICATION

CAS RN

121062-08-6 (free base)

EINECS RN

  

FORMULA

 C50H69N15O9

MOLE WEIGHT

 1024.18

H.S CODE

 2924.19.8000

SMILES

 [nH]1cncc1C[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C @@H] (Cc2c [nH]c3 ccccc23)C(N[C@@H](CCCCNC(C[C@@H](C(N1)=O) NC(=O)[C@ H](CCCC)NC(=O)C)=O) C(N)=O)=O)CCCNC(N)=N) Cc1ccccc1

CLASSIFICATION

 Melanocortin receptor agonist, Erectile dysfunction drug, Aphrodisiac

EXTRA NOTES

 Melanotan II is a MC3-R/MC4-R melanocortin agonist.
Synthetic cyclic heptapeptide, an analog of alpha-melanotropin (4,10); capable of stimulating melanin synthesis & promoting rapid tanning of skin; currently in trials for use in the prevention of sunlight-induced skin cancer.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2,Flammability:1, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Melanotan-II

Google Scholar Search - Melanotan II

Drug Information Portal (U.S. National Library of Medicine) - Melanotan II

PubChem Compound Summary - Melanotan-II

Drug Bank -  Melanotan-II

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Melanotan-II

http://www.ebi.ac.uk/ - Melanotan-II

http://www.ncbi.nlm.nih.gov/ - Melanotan-II

http://www.melanotan.nl/
Melanotan II was developed by researchers at the University of Arizona College of Medicine. Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH), this hormone provides a therapeutic tan with the ability to lower the risk of skin cancer, (MSH) also plays an important role in regulating sexual arousal in men and women. Melanotan II has the additional effect of decreasing body fat mass and is known to suppress the appetite. Melanotan II is a cyclic lactyam analog of alpha-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. Melanotan II is in a class of peptide hormones known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals.

http://www.researchpeptides.info/
Melonotan tanning peptide binds to melanocortin receptor and influence pigmentation, inflammation, energy, appetite and sexual function. Melanotan II has a small proactive amino acid structure that shows effect at the melonocortin 1, 3, 4 and 5 receptors. The central of Melanocortin system controls the food intake and weight of body. Usually, disruption of Melonocortin receptor (MCR) has been found in the cases of obesity. Melonocortins have also direct effect on adipocytes through lipid mobilization. Melanocortin peptides can be used to improve insulin sensitivity by stimulating fatty acid oxidation.

 

SALES SPECIFICATION

APPEARANCE

white powder

ASSAY

95.0~105.0% (on Anhydrous, Acetic Acid free basis)

OPTICAL ROTATION

-50° ~ -60° (c=0.5, 10% HAc)

WATER

5.0% max (Karl Fischer)

ACETATE CONTENT

15.0% max (HPLC)

AMINO ACID COMPOSITION

±10% theoretical

IMPURITY

1.0% max (Individual), 3.0% max (Total)

PEPTIDE PURITY

98.0% min (by %N)

BACTERIAL ENDOTOXINS

5EU/mg max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not known

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Avoid contact and inhalation. May causes eye irritation. May causes skin irritation. May cause gastrointestinal irritation. May causes respiratory tract irritation
HAZARD CODES

 

RISK PHRASES

  

SAFETY PHRASES

22-24/25

 

PACKING