MENADIONE

PRODUCT IDENTIFICATION
CAS NO. 58-27-5

MENADIONE

EINECS NO. 200-372-6
FORMULA C11H8O2
MOL WT. 172.18

H.S. CODE

  

TOXICITY

 
SYNONYMS Menaphthon; Menaphthone; Menaquinone 0; Mitenon; Mitenone;
2-Methylnaphthoquinone; Vitamin K 3; Vitamin K3; 2-Methyl-1,4-naftochinon; 2-Methyl-1,4-naphthalenedione; 2-Methyl-1,4-naphthochinon; 2-Methyl-1,4-naphthoquinone; 2-Methylnaphthoquinone; 3-Methyl-1,4-naphthoquinone; Aquakay; Aquinone; K-Thrombyl; K-Vitan; Memodol; Menadion; Menadionum; Thyloquinone; Vitamin K0; Vitamin K2(0);
DERIVATION  

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to creamy crystalline powder
MELTING POINT 105 - 107 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 2 Flammability: 1 Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Vitamin K is a group of compounds that are needed for the synthesis of certain proteins that help control bleeding. Vitamin K prevents bleeding by increasing hepatic biosynthesis of prothrombin and other coagulation factors. It is also needed for healthy bones. Vitamin K is a fat-soluble liquid that are biologically inactive when exposed to light or alkali. There are two forms naturally, phytonadione (vitamin K1) and menaquinone (vitamin K2). Phytonadione occurs in plants and is consumed in the diet. Menaquinone is produced by bacteria in the intestine. All of these compounds have the basic structure of methylated naphthoquinone and aliphatic side chain substituents. Phytonadione have its substituent of four isoprene units , one of which is unsaturated (phytyl substituent at 3 position). Menaquinones have side chains composed of a variable number of isoprene units; designated as MK-n, where n specifies the number of isoprene units.. The number of  isoprene unit varies lipophilicity for the different function of intestinal absorption, transport, tissue distribution, and bio-availability. Menadione (vitamin K3) is a synthetic form which does not have aliphatic side chain. Menadione is a vitamin precursor of V-K2 which can be converted in the liver to active menaquinones by chemical alkylation in vivo. Menadione Is used as a source of vitamin K in the treatment of hypoprothrombinemia against vitamin K deficiency. It is not used directly as a nutritional supplement due to high toxicity and low stability. Menadione sodium bisulfite (MSB) is a water-soluble derivative of menadione for feed. But MSB has limited stability to light, heat, humidity, ambient pH values above neutrality and in the presence of some salts. Menadione dimethyl pyrimidinol bisulfite (MPB) and menadione nicotinamide bisulfite (MNB) are other synthetic forms that have higher stability nut low solubility in water than MSB.

Molecular compounds of vitamin K

Menadione 58-27-5
2-Methyl-4-amino-1-naphthol 83-70-5
Menadiol bis(dihydrogen phosphate) 84-98-0
Phytonadione 84-80-0
Menaquinone 6 84-81-1
Menadione bisulfite 130-36-9
2-Methyl-4-amino-1-naphthol hydrochloride 130-24-5
Menadione sodium bisulfite anhydrous 130-37-0
Menadiol sodium diphosphate anhydrous 131-13-5
Menadiol 481-85-6
N-(4-Hydroxy-3-methyl-1-naphthyl)acetamide 523-68-2
Menaquinone 9 523-39-7
Menaquinone 8 523-38-6
Menaquinone 10 523-40-0
Phytonadiol 572-96-3
Acetomenaphthone 573-20-6
Phytonadiol diacetate 604-87-5
Menatetrenone 863-61-6
gamma-Hydroxyvitamin K 1181-23-3
2-Chlorophylloquinone 1258-63-5
Menadiol sodium sulfate 1612-30-2
Menaquinone 7 2124-57-4
Menadoxime 6146-99-2
Menadione sodium bisulfite trihydrate 6147-37-1
Menadiol sodium diphosphate hexahydrate 6700-42-1
Vitamin K2 11032-49-8
Vitamin K1 11104-38-4
Vitamin K 12001-79-5
Menadione dimethylpyrimidinol bisulfite 14451-99-1
Menadione epoxide 15448-59-6
Phytonadione hydroperoxide 15576-39-3
Phytonadione oxide 25486-55-9
Demethylmenaquinone 29790-47-4
2,5-Dimethyl-2-(4,8,12-trimethyltridecyl)-2H-naphtho(1,2-b)pyran-6-ol 34044-00-3
Menadione semiquinone 34524-96-4
Phylloquinone aglycone II 34927-45-2
Tetrahydromenaquinone 49852-77-9
3-Bromomethylmenadione 50371-29-4
Phylloquinone aglycone I 51732-61-7
Menadiol dibutyrate 53370-44-8
Menadione nicotinamide bisulfite 73581-79-0
Phylloquinone aglycone III 77179-33-0
Phytonadione epoxide-1,4-diol 81382-12-9
3-Hydroxy-2,3-dihydrophytonadione 82162-05-8
Osteocalcin 104982-03-8
2-Trifluoromethylmenaquinone 119052-96-9
2-Trifluoromethylphylloquinone 119052-95-8
SALES SPECIFICATION

APPEARANCE

 white crystalline powder

IDENTIFICATION

Conforms

ASSAY

98.5 - 101.5%

RESIDUE ON IGNITION

0.1% max
LOSS ON DRYING

0.5% max
HEAVY METALS

20ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26-36