MINOXIDIL

PRODUCT IDENTIFICATION
CAS NO. 38304-91-5MINOXIDIL
EINECS NO.

253-874-2

FORMULA C9H15N5O
MOL WT. 209.25

TOXICITY

 Oral Rat LD50: 1321mg/kg

H.S. CODE

 2933.59.5900
SYNONYMS Minoxidil; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide;

2,4-Diamino-6-piperidinopyrimidine 3-N-oxide; 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine; 2,4-Diamino-6-piperidinilpirimidina-3-ossido; 2,4-Diamino-6-piperidinopyrimidine 3-oxide; 2,6-Diamino-4-piperidinopyrimidin-1-oxide; Alopexil; Alostil; Loniten; Lonolox; Rogaine; Minodyl; Minossidile; Minoxidil; Minoxidilum; Minoximen; Prexidil; Theroxidil; 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine; 6-Piperidino-2,4-diaminopyrimidine 3-oxide;
SMILES c1(N2CCCCC2)cc(n(=O)c(n1)N)N

CLASSIFICATION

Piperidine, Vasodilator, Potassium channel opener, Antihypertensive, Cardiovascular agent, Hair growth stimulant

EXTRA NOTES

 A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
Activates ATP-activated K+ channels; vasodilator; hair growth stimulant.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white crystalline powder
MELTING POINT

272 - 274 C

BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER 2200 mg/l
SOLVENT SOLUBILITY  
pKa 4.61 (Dissociation Constant at 25 C)
log P 1.24 (Octanol-water)
VAPOR PRESSURE 1.03E-07 (mmHg at 25 C)
HENRY LAW CONSTANT 2.12E-16 (atm-m3/mole at 25 C)
OH RATE CONSTANT 2.26E-10 (cm3/molecule-sec at 25 C Atmospheric)

REFRACTIVE INDEX

  

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Minoxidil

PubChem Compound Summary - Minoxidil

Drug Bank -  Minoxidil

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Minoxidil

http://www.ebi.ac.uk/chebi/ -  Minoxidil

http://www.ncbi.nlm.nih.gov/ -  Minoxidil

http://divineskin.com/
Minoxidil: mechanisms of action on hair growth

http://www.nejm.org/
Minoxidil — An Alternative to Nephrectomy for Refractory Hypertension

http://jpet.aspetjournals.org/
Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

pass Tests

PURITY

97.5 - 102.5%

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.5% max

HEAVY METALS

20ppm max

IMPURITY

1.5% max (total)

As

1ppm max

Pb

1ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO. Not regulated
SAFETY INFORMATION

HAZARD OVERVIEW

Target Organ Effect, Harmful by ingestion., Irritant. Target Organs: Cardiovascular system.

GHS

 
SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

PRECAUTIONARY STATEMENTS

P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if  present and easy to do. Continue rinsing.
EC DIRECTIVES

 
HAZARD CODES

Xn Harmful

RISK PHRASES

22  Harmful if swallowed
36/37/38  Irritating to eyes, respiratory system and skin

SAFETY PHRASES

26  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36  Wear suitable protective clothing

PRICE INFORMATION