NALOXONE HYDROCHLORIDE DIHYDRATE

PRODUCT IDENTIFICATION
CAS NO. 51481-60-8

NALOXONE 

EINECS NO. 206-611-0
FORMULA C19H21NO4·HCl·2H2O
MOL WT. 399.87

H.S. CODE

  

TOXICITY

  
SYNONYMS (-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride dihydrate;
17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate; 17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate; Nalonee; (5alpha)-17-Allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder
MELTING POINT 200 - 205 C
BOILING POINT

 

RELATIVE DENSITY  
SOLUBILITY IN WATER

 

pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 Health: 2; Flammability: 1; Reactivity: 0

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Naloxone is an narcotic antagonist structurally related to oxymorphone (methyl group on the nitrogen is replaced by allylic group). It is derived from thebaine, a minor opiate alkaloid. The chemical name of The chemical name of naloxone is (-)-17-Allyl-4, 5a-epoxy-3,14-dihydroxymorphinan-6-one. Naloxone reverse opioid-induced respiratory depression, and as an adjunct in the treatment of sedation and hypotension. Naloxone blocks the action of alpha-agonists at opioid sites. It is a competitive antagonist for mu, kappa, delta, and sigma opioid receptors. Naloxone is specifically used to in emergency opioid overdose treatment. Structurally similar naltrexone is used for the long-term dependence treatment against opioid and alcohol addiction.

Naloxone compounds include:

Products

CAS RN.
Naloxone hydrochloride 357-08-4
Naloxone 465-65-6
6alpha-Naloxol 20410-95-1
Naloxone-3-ethereal sulfate 34707-87-4

Naloxone hydrochloride dihydrate

51481-60-8
6beta-Naloxol 53154-12-4
Methylnaloxonium 73232-50-5
Naloxazone 73674-85-8
Naloxone-6-spirohydantoin 87872-71-7
Estrone-naloxone azine 91712-59-3
6,6-Hydrazinaloxone 92078-77-8
6-Oximinonaloxone O-methyl ether 92078-81-4
Naloxone methiodide
93302-47-7
Naloxone benzoylhydrazone 119630-94-3
Mixture(Naloxone hydrochloride, Pentazocine hydrochloride) 126663-39-6
Misture(Buprenorphine, Naloxone) 352020-56-5
SALES SPECIFICATION

APPEARANCE

 white to off-white powder

CONTENT

98.0 - 101.0% (Dried Basis))

LOSS ON DRYING

11.0% max
SPECIFIC ROTATION -170° ~ -180°
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.

 

OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 22-24/25-26-36/37/39