PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

LD50 Oral rat: 1,653 mg/kg

Naxidine; Nizatidina; Nizatidine;

N-[2-[[2-(Dimethylaminomethyl)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-N'-methyl-2-nitroethene- 1,1-diamine; N-(2-(((2-((Dimethylamino)methyl)-4-thiazoly)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1- ethenediamine;  N-(2-(((2-((dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2- nitro-1,1-  ethenediamine; Acinon; Antizid; Axid; Calmaxid; Cronizat; Distaxid; Galitidin; Gastrax; N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamin; Panaxid; Splendil ER; Tazac; Ulcosol; Ulxid; Zanizal; Zinga; Nizatidinum; Nizax; Nizaxid;

c1(nc(CSCCN\C(=C\[N+](=O)[O-])NC)cs1)CN(C)C

CLASSIFICATION

Anti-ulcerative, Gastrointestinal agent, Histamine H2 antagonist

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

white to off-white crystalline powder

Soluble

REFRACTIVE INDEX

NFPA RATINGS

AUTOIGNITION

FLASH POINT

GENERAL DESCRIPTION & APPLICATIONS

Nizatidine is a histamine H₂ receptor antagonist, used to treat gastric and duodenal ulcers, gastroesophogeal reflux disease by inhibiting release of acid and pepsin into the stomach. It is an off-white to buff crystalline solid with a bitter taste and mild sulfur-like odor; soluble in water. Chemical designation is N-[2-[[2-(dimethylaminomethyl)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-N'- methyl-2-nitroethene- 1,1-diamine.

APPEARANCE

white to off-white crystalline powder

ASSAY

98.5 - 100.5%

1.0% max

HEAVY METALS

10ppm max

2ppm max

RESIDUE ON IGNITION

0.1% max

LOSS ON DRYING

0.5% max

TRETINOIN

5.0% max

Not regulated

HAZARD OVERVIEW

Target Organ Effect, Harmful by ingestion. Target Organs: Gastrointestinal tract

GHS

PICTOGRAMS

HAZARD STATEMENTS

H302

P STATEMENTS

RISK PHRASES

22

SAFETY PHRASES

36