NOBILETIN

Synonyms. Nobiletin; 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1- benzopyran-4-one; 3',4',5,6,7,8-Hexamethoxyflavone; Hexamethoxyflavone; 5,6,7,8,3',4'-Hexamethoxyflavone;

NOBILETIN

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

478-01-3

EINECS RN

 

FORMULA

 C21H22O8

MOLE WEIGHT

402.39

H.S CODE

 2932.99.6100

SMILES

 c12c(oc(cc2=O)c2cc(OC)c(cc2)OC)c(OC)c(c(c1OC)OC)OC

CLASSIFICATION

Flavone

EXTRA NOTES

 Nobiletin is a chemical compound. It is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine(Wikipedia)

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white powder

MELTING POINT

138 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY Soluble in chloroform

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents, Strong bases, moisture

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Nobiletin

Google Scholar Search - Nobiletin

Drug Information Portal (U.S. National Library of Medicine) - Nobiletin

PubChem Compound Summary - Nobiletin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Nobiletin

http://www.ebi.ac.uk/ - Nobiletin

http://www.ncbi.nlm.nih.gov/ - Nobiletin

HMDB
Nobiletin is found in citrus. Nobiletin is isolated from peel of king orange (Citrus nobilis), seville orange (Citrus aurantium) and other Citrus species, and the round kumquat (Fortunella japonica) Nobiletin has been shown toexhibit angiogenic, anti-tumor, anti-inflammatory and anti-angiogenic functions (PMID 20670297, 15252145, 12787887, 20670297). Nobiletin belongs to the family of Flavones. These are flavonoids whose structure is based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one).

http://www.phytochemicals.info/
Nobiletin is a citrus flavonoids with a structure similar to that of tangeretin. It has the typical flavonoid structure and contains 6 methoxyl groups, one more than tangeretin. This high level of methoxylation increases the hydrophobic character of tangeretin. Pure nobiletin has the appearance of colorless needles and has a bitter taste.

 

SALES SPECIFICATION

APPEARANCE

white powder

CONTENT

98.0% min

LOSS ON DRYING

5.0% max

HEAVY METALS

20ppm max

MELTING POINT

136 ~ 140 C

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be harmful if swallowed.

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 26-36

 

PACKING

Preserve in light-resistant and well-closed containers