NORCANTHARIDIN

PRODUCT IDENTIFICATION
CAS NO. 5442-12-6, 29745-04-8

NORCANTHARIDIN

EINECS NO.

 

FORMULA C8H8O4
MOL WT. 168.15

H.S. CODE

 2932.99.9000

TOXICITY

 
SYNONYMS Endothall anhydride; Norcantharidin;
(3a-alpha,4-beta,7-beta,7a-alpha)-Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; exo-7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride; Hexahydro-3,6-endooxyphthalic anhydride; 3,6-Endoxohexahydrophthalic anhydride; Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride; Hexahydro-3,6-endoxo-phthalic anhydride;
SMILES C1C[C@@H]2[C@@H]3C(=O)OC(=O)[C@@H]3[C@@H]1O2

CLASSIFICATION

 Acid Anhydride

EXTRA NOTES

Potential antitumor agent

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: ; Flammability: ; Reactivity:

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Norcantharidin

Google Scholar Search

PubChem Compound Summary - Norcantharidin

http://www.ebi.ac.uk/chebi/ - Norcantharidin

http://www.ncbi.nlm.nih.gov/
Norcantharidin: A potential antiangiogenic agent for gallbladder cancers in vitro and in vivo.

http://www.academicjournals.org/
Norcantharidin (NCTD), a demethylated form of cantharidin, is now in used as a routine anticancer drug. However, the detailed mechanisms underlying this process are generally unclear. The aims of this study were to evaluate the apoptotic effects and molecular mechanisms of NCTD. MTT assay was used to determine the cell growth inhibitory rate. Flow cytometry were used to detect the apoptosis and the loss of mitochondrial membrane potential (∆ψm) induced by NCTD. Caspase detection kit were used to detect the activity of caspase-3 -9. Western-blot was used to detect the expression of Bcl-2, Bax and cytochrome C (cyt C). Our results indicated that, treatment of NCTD resulted in significant decrease in cell viability in a dose-and time-dependent manner. A dose-dependent apoptosis was also observed by flow cytometery analysis. Molecular mechanistic studies of apoptosis revealed that, NCTD treatment resulted in a significant loss of ∆ψm, release of cyt C, enhanced expression of pro-apoptotic protein Bax and suppression of anti-apoptotic protein Bcl-2. These were followed by activation of caspases-9 and -3, subsequently leading to cell apoptosis. These results indicate that, NCTD induced cytotoxicity in HepG2 cells by apoptosis, which is mediated through mitochondrial pathway.
SALES SPECIFICATION

APPEARANCE

 white powder

IDENTIFICATION

passes Test A,B (HPLC, UV)

ASSAY

98.0% min

LOSS ON DRYING

0.5% max

PESTICIDE RESIDUE

2ppm max

HEAVY METAL

20ppm max

TOTAL PLATE COUNT

1000cfu/gm max

SALMONELLA

Negative

ESCHERICHIACOLI

Negative

PARTICLE SIZE

80 mesh
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.

Not known

SAFETY INFORMATION

Hazard Overview

Not known
PRICE INFORMATION