ORIDONIN

Synonyms. Oridonin; 7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one; (1-alpha,6-beta,7- alpha,14R) -7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one; (14R)-7-alpha,20-Epoxy-1 -alpha,6- beta, 7,14-tetrahydroxykaur-16-en-15-one; Isodonol; Rubescensin; Rosmarinic acid;

ORIDONIN

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

28957-04-2

EINECS RN

 

FORMULA

 C20H28O6

MOLE WEIGHT

364.43

H.S CODE

 2935.00.9500

SMILES

 C1([C@@]23[C@@H]([C@@]45[C@@H](C(CC[C@@H]5O)(C)C) [C@@H] ([C@@] 2(OC4)O)O)CC[C@@H]([C@@H]3O)C1=C)=O

CLASSIFICATION

Gastrointestinal agent

EXTRA NOTES

 Kaurene-type diterpenoid from Isodon.
Other RN: 18288-82-9

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

248 ~ 250 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Insoluble

SOLVENT SOLUBILITY Soluble in DMSO

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Oridonin

Google Scholar Search - Oridonin

Drug Information Portal (U.S. National Library of Medicine) - Oridonin

PubChem Compound Summary - Oridonin

Drug Bank -  Oridonin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Oridonin

http://www.ebi.ac.uk/ - Oridonin

http://www.ncbi.nlm.nih.gov/ - Oridonin

http://mct.aacrjournals.org/
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways...

http://www.biomedcentral.com/
Oridonin, an ent-kaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy. Studies showed that oridonin induced apoptosis in a variety of cancer cells including those from prostate, breast, non-small cell lung cancer, acute leukemia, glioblastoma multiforme and human melanoma cells. Cell culture experiments have indicated that oridonin inhibits cell cycle progression and induces apoptosis as well as enhance the phagocytosis of apoptotic cells by macrophages. Oridonin has also immunosuppressive properties both in vitro and in vivo. However, mechanisms underlying the antitumor activity of oridonin and whether oridonin has the anti-colorectal cancer activity remain largely unknown....

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

positive (IR)

ASSAY

98.0% min

MELTING POINT

248 ~ 250 C
SPECIFIC ROTATION

-45° ~ -497° (c =1 in C5H5N)
LOSS ON DRYING

1.0% max

HEAVY METALS

10ppm max
RESIDUE ON IGNITION

0.2% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Suspected of causing cancer. May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. May be harmful if swallowed.

GHS

  

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H351

P STATEMENTS

P287

EC DIRECTIVES

 

HAZARD CODES

Xn

RISK PHRASES

40

SAFETY PHRASES

 36/37

 

PACKING