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PHLORETIN |
| Synonyms. Phloretin; Phloretol; 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; 4,2',4',6'-Tetrahydroxydihydrochalcone; beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; beta-(p-Hydroxyphenyl)phloropropiophenone; Dihydronaringenin; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
60-82-2 |
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EINECS RN |
200-488-7 |
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FORMULA |
C15H14O5 |
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MOLE WEIGHT |
274.27 |
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H.S CODE |
2914.50.3000 |
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SMILES |
c1(C(CCc2ccc(O)cc2)=O)c(cc(O)cc1O)O |
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CLASSIFICATION |
Calcium Channel Modulator |
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EXTRA NOTES |
Biochem/physiol Actions:Blocks L-type Ca2+ channels; activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers. Monocarboxylate transporter inhibitor.
Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules. General description: Major polyphenol found in apple; aglycone of phloridzin.(http://www.sigmaaldrich.com/) |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
White to yellowish powder |
MELTING POINT |
260 ~ 263 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
123 mg/l |
| SOLVENT SOLUBILITY | Soluble in methanol |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pKa |
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REFRACTIVE INDEX |
1.573 ~ 1.575 |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions.Light sensitive |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 0, Flammability:0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Phloretin Google Scholar Search - Phloretin Drug Information Portal (U.S. National Library of Medicine) - Phloretin PubChem Compound Summary - Phloretin Drug Bank - Phloretin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Phloretin http://www.ebi.ac.uk/ - Phloretin http://www.ncbi.nlm.nih.gov/ - Phloretin
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| SALES SPECIFICATION | |
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APPEARANCE |
White to yellowish powder |
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ASSAY |
98.0% min |
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LOSS ON DRYING |
5.0% max |
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HEAVY METALS |
10ppm max |
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As |
1ppm max |
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Pb |
3ppm max |
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MICROBIOLOGICAL TEST |
Total Plate Count: 1000 organisms/g max |
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PARTICLE SIZE |
100 mesh |
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| TRANSPORT & REGULATORY INFORMATION |
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UN NO. |
Not regulated |
| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION |
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HAZARD OVERVIEW |
Irritating to eyes, respiratory system and skin. Target Organs: Skin, Respiratory system, Eyes |
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GHS |
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SIGNAL WORD |
Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H315-H319-H335 |
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P STATEMENTS |
P261-P302+ P352-P305 + P351 + P338 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
36/37/38 |
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SAFETY PHRASES |
26-37/39 |
