PRODUCT IDENTIFICATION

68890-66-4
50650-76-5 (free from)

272-574-2

TOXICITY

H.S. CODE

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt; Kopirox; Octopirox;  

CLASSIFICATION

Antiseborrheic, 2-Pyridinone, Hydroxamic acid

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

130 - 135 C

pH

8.5 – 10.0 (1% aq. solution)

REFRACTIVE INDEX

NFPA RATINGS

Health hazard: 1, Fire: 0, Reactivity Hazard: 0

AUTOIGNITION

FLASH POINT

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Piroctone olamine

PubChem Compound Summary - Piroctone olamine

Drug Bank -  Piroctone olamine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Piroctone olamine

http://www.ebi.ac.uk/chebi/ -  Piroctone olamine

http://www.ncbi.nlm.nih.gov/ -  Piroctone

http://journal.scconline.org/
The" half-headt"e chniqucea nb eu seda sa suitablaen dr eliablem ethodfo r comparativeev aluatioonf the efficacyo f antidandruaffg entsT. wo modeso f experimentadle signw hichd ifferi n schedulaen ds coring systema re describedD. ata areg ivenf or shampooasn d creamr insesc ontainingth e new antidandruff agent PIROCTONE OLAMINE [1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolaminsea lt]i n comparisotno thec orrespondingo nmedicatefodr mulationass w ella st o thes ame shampoboa sesc ontaininZgI NC PYRITHIONE as a knowne fficaciouasn tidandruaffg entP. iroctone olamineh asb eend emonstratetdo be highlye ffectivein the treatmenot f dandruffa nd more effective thanz incp yrithionaet the samec oncentratio(pn < 0.05).A n appreciabeleff ecto n skinl ipidr egeneration ratec ouldn ot be measuredA. tentativee xplanatiofno r the oftenp erceivedin creasien scalpa nd hair oilinesasf tert he useo f antidandrupffr oductiss advance

http://www.vetcontact.com/
Piroctone olamine (PO), also called Octopirox, is an antifungal of the hydroxy-pyridone family unrelated to other antiseptics used in veterinary medicine. Members of the “pirox” family are currently used in the human field as topicals to cure onychomycosis and Malassezia-related skin disorders. PO has broad in vitro activity against major dermal veterinary pathogens, including dermatophytes and yeasts as well as some Gram positive (Staphylococcus) and Gram negative (Pseudomonas) bacteria (Markus, 1999). As opposed to azole derivatives, PO remains fully active on resting fungal cells; its antiseptic activity proceeds from inhibition of the respiratory chain in yeast mitochondria (Bohn and Kraemer 2000). No resistance to PO has been documented to date. In addition, this antiseptic acts at low concentrations, has high affinity for keratin and is completely safe. Incorporation of PO in Allermyl therefore aims at controlling microbial proliferation associated with allergic disease.

APPEARANCE

IDENTIFICATION

pass Tests

CONTENT

99.0% min

AMINO ETHANOL

20 - 21%

MELTING POINT

130 - 135 C

LOSS ON DRYING

0.3% max

ASH

0.2% max

pH VALUE

8.5 – 10.0 (1% aq. solution)

HEAVY METALS

20ppm max

HAZARD OVERVIEW

Not known

GHS

RISK PHRASES

 36/37/38 Irritating to eyes, respiratory system and skin

SAFETY PHRASES

26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice