POLYDATIN

Synonyms. Polydatin; Piceid; Polydotin peceid; Reservatrol-3-beta-mono-D-glucoside; Resveratrol 3-O-beta-D-glucopyranoside; 3,4,5-Trihydroxystilbene-3-beta-monoglucoside; Other RN: 28759-35-5, 32095-27-5, 58462-72-9

POLYDATIN

 

PRODUCT IDENTIFICATION

CAS RN

65914-17-2, 27208-80-6 (trans Form)

EINECS RN

  

FORMULA

C20H22O8

MOLE WEIGHT

 390.38

H.S CODE

 2938.90.0000

SMILES

 O1[C@H]([C@@H]([C@H]([C@@H](O)[C@H]1CO)O)O)Oc1cc (cc(\C=C\c2ccc(O)cc2)c1)O

CLASSIFICATION

Stilbenoid

EXTRA NOTES

 A stilbenoid glucoside and is a major resveratrol derivative in grape juices.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white powder

MELTING POINT

 

BOILING POINT

223 - 226 C

DENSITY

 

SOLUBILITY IN WATER

Soluble

SOLVENT SOLUBILITY Soluble in ethyl acetate, DMSO

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pKa

 

REFRACTIVE INDEX

 

FLASH POINT

267 C

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents, Strong bases

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Piceid

Google Scholar Search - Polydatin

Drug Information Portal (U.S. National Library of Medicine) - Polydatin

PubChem Compound Summary - Polydatin

Drug Bank -  Polydatin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Polydatin

http://www.ebi.ac.uk/ - Polydatin

http://www.ncbi.nlm.nih.gov/ - Polydatin

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank -  Polydatin

http://www.sciencedirect.com/
Polydatin is one of the most common encountered stilbenes of nature and a key component of the Chinese herb Polygonum cuspidatum. This study is to investigate the effects of polydatin on learning and memory impairments induced by chronic cerebral hypoperfusion in rats, as well as the potential mechanism. Both common carotid arteries and both vertebral arteries occlusion (four-vessel occlusion, 4-VO) induced severe cognitive deficits tested by water maze task, along with oxidative stress in hippocampus. Oral administration of polydatin for 30 days markedly attenuated cognitive deficits compared with the control (p < 0.05). Biochemical determination revealed that polydatin decreased the production of malondialdehyde (MDA) and significantly increased the activities of superoxide dismutase (SOD) and catalase (CAT). Additionally, polydatin effectively alleviated the injuries of cultured neurons induced by oxygen-glucose deprivation (OGD). These results suggest that polydatin exhibit therapeutic potential for vascular dementia, which is most likely related, at least in part, to its anti-oxidant activity and the direct protection of neurons.

 

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

98.5% min

ASH

0.5% max

LOSS ON DRYING

5.0% max

PESTICIDE RESIDUE

non

SPECIFIC ROTATION

-68° ~ -62° (c=1 in ehtanol)

HEAVY METALS

10ppm max

PARTICLE SIZE

80 mesh

MICROBIOLOGICAL TEST

Total Plate Count: 1000CFU/g max
Total Yeast & Mold: 100CFU/g max
Salmonella: Negative
E.Coli: Negative

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not known

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Not known
HAZARD CODES

 

RISK PHRASES

  

SAFETY PHRASES

 24/25

 

PACKING