PREDNIMUSTINE

Synonyms. Prednimustine; 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(4-(p- (bis(2-chloro ethyl) amino)phenyl)butyrate); Prednimustina; Prednimustine; Prednimustinum; Chlorambucil prednisolone ester; Prednisolone 21-(4-(p-(bis(2-chloroethyl)amino)phenyl)butyrate); Sterecyt; Stereocyt;

PREDNIMUSTINE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

29069-24-7

EINECS RN

 249-410-3

FORMULA

C35H45Cl2NO6

MOLE WEIGHT

 646.64

H.S CODE

 2922.49.3700

SMILES

 C1[C@H]2[C@H]3[C@@]([C@](C(COC(CCCc4ccc(N(CCCl)CCCl)cc4)= O)=O) (O)CC3)(C[C@@H]([C@@H]2[C@@]2(C(=CC(=O)C=C2)C1)C)O)C

CLASSIFICATION

Alkylating agent, Antineoplastic

EXTRA NOTES

 Ester of chlorambucil and prednisolone used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity. (Mesh)
Overall Carcinogenic Evaluation: Group 3

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

163 ~ 164 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pKa

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 0, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Prednimustine

Google Scholar Search - Prednimustine

Drug Information Portal (U.S. National Library of Medicine) - Prednimustine

PubChem Compound Summary - Prednimustine

Drug Bank -  Prednimustine

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Prednimustine

http://www.ebi.ac.uk/ - Prednimustine

http://www.ncbi.nlm.nih.gov/ - Prednimustine

http://monographs.iarc.fr/
2.1 Production and occurrence: Prednimustine can be produced by the esterification of chlorambucil with prednisolone (Fex et aL., 1970). It is synthesized in Sweden. Prednimustine is not known to occur naturally. 2.2 Use: Prednimustine is a cytostatic agent. It has been used in the treatment of various malignancies, including chronic lymphatic leukaemia and non-Hodgkin's lymphomas, at dailyoral doses of 140-20 mg for three to five days or continuously at 20-30 mg per day (Reynolds, 1989; Szanto et al., 1989). It has also been tested for use in the treatment of breast cancer (Lober et al., 1983; Rankin et al., 1987).....

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

98.5% min

MELTING POINT

163 ~ 164 C
IMPURITY

1.0% max (total), 0.5% max (individual)

LOSS ON DRYING

1.0% max

HEAVY METALS

20ppm max

OPTICAL ROTATION

+92.0°~ +94.0°(c = 1.06 in chloroform)

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

 6.1
PACKING GROUP III