PTEROSTILBENE

PRODUCT IDENTIFICATION
CAS NO. 537-42-8 (trans-)
441351-32-2 (cis-)

PTEROSTILBENE 

EINECS NO.  
FORMULA C16H16O3
MOL WT. 256.30

H.S. CODE

 2909.50.4500

TOXICITY

  
SYNONYMS 4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol;
Pterostilbene;  (E)-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol; (E)-3',5'-Dimethoxy-4-dtilbenol; 3,5-Dimethoxy-4'-hydroxy-trans-stilbene; 4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol; 3',5'-Dimethoxy-4-stilbenol;
SMILES

c1(ccc(cc1)\C=C\c1cc(cc(c1)OC)OC)O

CLASSIFICATION

 

EXTRA NOTES

 Biochem/physiol Actions:Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

off-white crystalline powder

MELTING POINT

85 - 88 C

BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble (DMSO: 20 mg/ml)
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Pterostilbene

Google Scholar Search - Pterostilbene

Drug Information Portal (U.S. National Library of Medicine) - Pterostilbene

PubChem Compound Summary - Pterostilbene

Drug Bank -  Pterostilbene

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Pterostilbene

http://www.ebi.ac.uk/ - Pterostilbene

http://www.ncbi.nlm.nih.gov/ - Pterostilbene

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Pterostilbene

Local:
Resveratrol (3,5,4'-trihydroxystilbene) is a non-flavonoid polyphenolics compound found highly in the skin of red grapes and as a constituent of red wine. It is also found in teas, berries and peanuts. Resveratrol is a compound of stilbene structure (and is responsible for the principle coloring of the plants. Resveratrol is created by plants as a phytoalexin (plant's defense arsenal) against bacteria and fungi. It is marketed as a nutritional supplement that shows health-giving antioxidant effects such as anti-cancer, antiviral, and anti-aging. Resveratrol inhibits COX-1 enzyme and demonstrates anti-inflammatory effects. It is a platelet aggregation inhibitor to block the adhesion of blood cells to vessel walls and therefore prevents heart disease and cerebral apoplexy.  It exists as two structural isomers: cis- (Z) and trans- (E),

Piceatannol or 3,4,3',5'-tetrahydroxy-trans-stilbene is a phenolic that is structurally related to resveratrol. Piceatannol has one more hydroxyl group at 3' position. It is a metabolite of resveratrol and is found in red wine. Pterostilbene (3,5-Dimethoxy-4'-hydroxy-trans-stilbene) is an analog of resveratrol. The two phenolic hydroxyl groups among three are converted to methyl ethers. Some reports say that the ethers enhance antioxidant effects. Pterostilbene is also know as a Hypoglycemic agent and Apoptosis Inducer. Some examples of Apoptosis Inducer include:

Product

CAS RN.

Tanespimycin

75747-14-7
2-Amino-N-quinolin-8-yl-benzenesulfonamide 16082-64-7

5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic Acid

 300817-68-9
Borrelidin 7184-60-3
Brefeldin A 20350-15-6
Bufalin 465-21-4
6-(4-Hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic acid 125316-60-1
1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone 479077-76-4
Carboxyatractylate 35988-42-2
Dimethyloxoxanthene acetic acid 117570-53-3
Fluticasone propionate 80474-14-2
Imiquimod 99011-02-6
Neocarzinostatin 9014-02-2
Nutlin-3 548472-68-0
Pterostilbene 537-42-8
SALES SPECIFICATION

APPEARANCE

off-white to yellowish crystalline powder
ASSAY

98.0% min (HPLC)

LOSS ON DRYING

0.5% max

ASH

0.1% max

HEAVY METALS

20ppm max

MICROBIOLOGICAL TEST

Total Plate Count: 1000CFU/G max
Mold and Yeast: 100CFU/G max
E.coli: Non-detective
Salmonella: Non-detective
TRANSPORTATION
PACKING
 
HAZARD CLASS 9 (Packing Group: 3)
UN NO. 3077
SAFETY INFORMATION

HAZARD OVERVIEW

May be harmful if swallowed. Causes serious eye damage. Toxic to aquatic life with long lasting effects

GHS

 
SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H318-H411

P STATEMENTS

P273-P280-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

41-51/53

SAFETY PHRASES

26-39-61