SECNIDAZOLE

PRODUCT IDENTIFICATION
CAS NO. 3366-95-8

SECNIDAZOLE

EINECS NO. 222-134-0
FORMULA C7H11N3O3
MOL WT. 185.18

H.S. CODE

  

TOXICITY

 
SYNONYMS alpha,2-Dimethyl-5-nitroimidazole-1-ethanol;
1-(2-Hydroxypropyl)-2-methyl-5-nitroimidazol; 1-(2-Methyl-5-nitro-1-imidazolyl)-2-propanol; Secnidazol; Secnidazolum; 1-(2-Methyl-5-nitroimidazol-1-yl)propan-2-ol;
DERIVATION  

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE off-white to yellowish crystalline powder
MELTING POINT 78 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
"Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. These drugs share a common spectrum of activity against anaerobic micro-organisms and they appear particularly effective in the treatment of amoebiasis, giardiasis, trichomoniasis and bacterial vaginosis. Secnidazole is rapidly and completely absorbed after oral administration and has a longer terminal elimination half-life (approximately 17 to 29 hours) than commonly used drugs in this class. in patients with intestinal amoebiasis or giardiasis, clinical or parasistological cure rates of 80 to 100% are achieved after treatment with a single dose of secnidazole 2g (30 mg/kg in children), similar to the response rates achieved with multiple dosage regimens of metronidazole or tinidazole. (source: http://www.ncbi.nlm.nih.gov/pubmed/8706597)"

Nitroimidazole (or heterocycles such as nitrothiazole) structural compounds are used as an anti-infective agent for the treatment of infections caused by amebiasis, vaginitis, trichomonas, giardiasis, treponemal, particularly anaerobic bacteria and protozoa. Nitroimidazole structure is a radiation sensitizer for hypoxic cells. It is involved in redox recycling by the redox enzyme and then disrupt the DNA helical structure, resulting in inhibiting nucleic acid synthesis.

Antibiotics (Nitroimidazole structure)

Product

CAS RN
Metronidazole 443-48-1
Dimetridazole 551-92-8
Ternidazole 1077-93-6
Secnidazole 3366-95-8
1-Methyl-2-(p-fluorophenyl)-5-nitroimidazole 4204-99-3
Flunidazole 4548-15-6
Chlomizole 4897-31-8
Nimorazole 6506-37-2
Ronidazole 7681-76-7
Misonidazole 13551-87-6
Panidazole 13752-33-5
Ornidazole 16773-42-5
Tinidazole 19387-91-8
Nitroimidazole thiadiazole 19622-55-0
Benznidazole 22994-85-0
5-Isopropyl-1-methyl-2-nitroimidazole 23571-34-8
2-Methyl-5-nitroimidazole-1-ethanol methanesulfonate 30746-54-4
Bamnidazole 31478-45-2
3a,4,5,6,7,7a-Hexahydro-3-(1-methyl-5-nitroimidazol-2-yl)-1,2-benzisoxazole 33450-08-7
Carnidazole 42116-76-7
Sulnidazole 51022-76-5
Moxnidazole 52279-59-1
2-Amino-4-(2-ethynyl-1-methyl-5-nitroimidazole)pyrimidine 53347-38-9
1,4-Bis(1-methyl-5-nitroimidazolyl-(2-methylenimino))piperazine 54093-05-9
Pirinidazole 55432-15-0
Miroprofen 55843-86-2
Satranidazole 56302-13-7
3a,4,5,6,7,8,9,9a-Octahydro-3-(1-methyl-5-nitroimidazol-2-yl)cycloocta(d)isoxazol 58211-94-2
Fexinidazole 59729-37-2
Azanidazole 62973-76-6
Metronidazole hydrochloride 69198-10-3
Pimonidazole 70132-50-2
Metronidazole phosphate 73334-05-1
Propenidazole 76448-31-2
Tivanidazole 80680-05-3
Abunidazole 91017-58-2
1-(2-Fluoroethyl)-2-nitroimidazole 104613-88-9

SALES SPECIFICATION

APPEARANCE

 off-white to yellowish crystalline powder

IDENTIFICATION

passes test A,B,C,D

ASSAY

98.5% min
LOSS ON DRYING 1.0% max
RESIDUE ON IGNITION 0.1% max
HEAVY METAL 10ppm max
pH 5 - 7
MELTING POINT > 70 C
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION