THIOSEMICARBAZIDE

PRODUCT IDENTIFICATION
CAS NO. 79-19-6

THIOSEMICARBAZIDE

EINECS NO. 201-184-7
FORMULA NH2CSNHNH2
MOL WT. 91.14

H.S. CODE

 

TOXICITY

 
SYNONYMS 2-Thiosemicarbazide; 3-Thiosemicarbazide; Aminothio-urea;
1-Amino-2-thiourea; 1-Amino-2-thiourea; 1-Aminothiourea; Hydrazinecarbothioamide; Isothiosemicarbazide; N-Aminothiourea; Thiocarbamoylhydrazine; Thiocarbamylhydrazine; Thiosemicarbazide;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 181 - 182 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Semicarbazide is an urea derivative in which one amide group of urea is replaced by hydrazine residue. The formula is H2NNHC(=O)NH2. The hydrochloride salt of semicarbazide is a white crystal; melting point 175 C; very soluble in water. It is used in preparing pharmaceuticals including nitrofuran antibacterials (furazolidone, nitrofurazone, nitrofurantoin) and related compounds. It is used as a derivatization reagent for aldehydes and ketones. It produces crystalline compounds with characteristic melting points with aldehydes and ketones and thus used as a derivation reagent. It is used as a solvent to separate hormones and essential oils. Semicarbazone is a ketone form of semicarbazide which is derived by the condensation reaction between a ketone (or aldehyde) and a semicarbazide, R2C=NNHC(=O)NH2. Thiosemicarbazone contains a sulfur atom in stead of oxygen in the ketone. Semicarbazone products Both semicarbazones and thiosemicarbazones are known to have an activity of antiviral, antiinfective and antineoplastic through binding to copper or iron in cells. Some examples are:

Product

Activity

CAS RN.
Nitrofurazone anti-infective agent, Trypanocidal agent 59-87-0
Carbazochrome Hemostatics 69-81-8
Carbazochrome sodium sulfonate

 

 51460-26-5
Subathizone Antitubercular agent 121-55-1
Nidroxyzone Chemotherapeutic 405-22-1
Ambazone Antineoplastic agent, Bacteriostatic 539-21-9
Nicothiazone Tuberculostatic 555-90-8
Methisazone Antiviral agent 1910-68-5
Naftazone

 

 15687-37-3
Gloxazone Veterinary Anaplasmodastat, Antineoplastic agent, Antiprotozoal agent 2507-91-7
Nifursemizone Antiprotozoal 5579-89-5
Nifurethazone

 

 5580-25-6
Ambazone

Antiseptic

 6011-12-7
Iprazochrome Serotonin antagonist 7248-21-7
Bitipazone

 

 13456-08-1
Citenazone Antiviral agent 21512-15-2
Pimagedine Enzyme inhibitor 79-17-4
Phenicarbazide Fungicide, bactericide 103-03-7
Dichlofluanid Fungicide, bactericide 1085-98-9
Tolazamide Antidiabetic, Hypoglycemic agent 1156-19-0
Goserelin Hormonal antineoplastic agent 65807-02-5
Ramorelix Hormone antagonist 127932-90-5
SALES SPECIFICATION

APPEARANCE

 white crystals

PURITY

99.0% min
MELTING POINT

181 - 182 C
TRANSPORTATION
PACKING
 
HAZARD CLASS 6.1 (Packing Group: II)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: T+, Risk Phrases: 28, Safety Phrases: 22-26-36/37-45