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| TROSPIUM CHLORIDE | ||||||||||||||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 10405-02-4 |
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| EINECS NO. | 233-875-4 | |||||||||||||
| FORMULA | C25H30ClNO3 | |||||||||||||
| MOL WT. | 427.96 | |||||||||||||
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H.S. CODE |
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TOXICITY |
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| DERIVATION |
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| CLASSIFICATION |
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| SYNONYMS | Keptan; Relaspium; Sanctura; Santura; | |||||||||||||
| 3alpha-Hydroxyspiro(1alphaH,5alphaH-nortropane-8,1'-pyrrolidinium) chloride benzilate; 8-alpha-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride; Azoniaspiro Compound XVII; Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride; Chlorure de trospium; Cloruro de trospio; Spasmex; Spasmo 3; (1alpha, 3beta, 5alpha)-3-((hydroxydiphenylacetyl)oxy) Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium) chloride; Trospii chloridum; | ||||||||||||||
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to off-white crystalline powder | |||||||||||||
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| SPECIFIC GRAVITY | ||||||||||||||
| SOLUBILITY IN WATER | soluble | |||||||||||||
| pH | ||||||||||||||
| VAPOR DENSITY |
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY |
Stable under ordinary conditions. |
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GENERAL DESCRIPTION & APPLICATIONS |
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Trospium chloride is a quaternary ammonium compound; white to off-white
crystalline powder; freely soluble in water (1 g/2 ml) and methanol, practically
insoluble in methylene chloride. The IUPAC designation is
[(1R,5S)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl]
2-hydroxy-2,2-diphenylacetate chloride. It is a muscarinic antagonist that
counteracts the effects of muscarine or blocks the muscarinic receptors.
Antispasmodic drugs suppress smooth muscle contraction, especially in tubular
organs. The effect is to prevent spasms of the stomach, intestine or bladder.
Muscarinic antagonist which reduces the activity of the muscarinic.
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| SALES SPECIFICATION | ||||||||||||||
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APPEARANCE |
white to off-white powder | |||||||||||||
| Identification |
Complies |
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ASSAY |
99.0 - 101.0% |
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| Loss on drying |
0.5% max |
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| Sulphated ash |
0.1 max |
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| Total impurity |
0.5% max |
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pH |
5.0 - 7.0 (1 % aqueous solution) | |||||||||||||
| Microbiological test |
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| TRANSPORTATION | ||||||||||||||
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| HAZARD CLASS | ||||||||||||||
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| OTHER INFORMATION | ||||||||||||||
| Hazard Symbols: XN, Risk Phrases: 20/21/22, Safety Phrases: 36 | ||||||||||||||
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