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URACIL MUSTARD |
| Synonyms. Uracil Mustard; 5-(Bis(2-chloroethyl)amino)-2,4-(1H,3H)-pyrimidinedione; 2,6-Dihydroxy- 5-bis(2-chloroethyl)aminopyrimidine; 5-(Bis(2-chlorethyl)amino)-2,4(1H,3H) pyrimidinedione; 5-(Bis(2-chloroethyl)amino)-2,4(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl) amino)uracil; 5-(Di-(beta-chloroethyl)amino)uracil; 5-(Di-2-chloroethyl)aminouracil; 5-Aminouracil mustard; 5-N,N-Bis(2-chloroethyl)aminouracil; Aminouracil mustard; Chlorethaminacil; Demethyldopan; Desmethyldopan; Uramustine; Uracillost; Uracilmostaza; Nordopan; Uramustin; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
66-75-1 |
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EINECS RN |
200-631-3 |
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FORMULA |
C8H11Cl2N3O2 |
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MOLE WEIGHT |
252.10 |
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H.S CODE |
2938.90.0000 |
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SMILES |
c1(N(CCCl)CCCl)c([nH]c(=O)[nH]c1)=O |
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CLASSIFICATION |
Alkylating agent, Antineoplastic |
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EXTRA NOTES |
Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
(MeSH) Overall Carcinogenic Evaluation: Group 2B |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white powder |
MELTING POINT |
206 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
1070 mg/l |
| SOLVENT SOLUBILITY | |
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VAPOR DENSITY |
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log P(octanol-water) |
0.64 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pKa |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 0, Flammability:0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Uramustine Google Scholar Search - Uracil Mustard Drug Information Portal (U.S. National Library of Medicine) - Uracil Mustard PubChem Compound Summary - Uracil Mustard Drug Bank - Uracil Mustard KEGG (Kyoto Encyclopedia of Genes and Genomes) - Uracil Mustard http://www.ebi.ac.uk/ - Uracil Mustard http://www.ncbi.nlm.nih.gov/ - Uracil Mustard |
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| SALES SPECIFICATION | |
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APPEARANCE |
off-white to yellow powder |
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ASSAY |
98.0% min |
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MELTING POINT |
205 C ~ 207 C |
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LOSS ON DRYING |
5.0% max |
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HEAVY METALS |
20ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
3249 |
| HAZARD CLASS |
61 |
| PACKING GROUP | II |
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| PACKING |
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