VINBLASTINE SULFATE

PRODUCT IDENTIFICATION
CAS NO. 143-67-9

VINBLASTINE SULFATE 

EINECS NO. 205-606-0
FORMULA C46H58N4O9·H2SO4
MOL WT. 909.05

H.S. CODE

  

TOXICITY

  

PRICE

 
SYNONYMS  
Rozevin sulfate; VLB monosulfate; Velban; Velbe; Velsar; Vinblastine 5; Vincaleucoblastine sulfate; (3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-methyl 4- (acetyloxy)- 3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7- methano azacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6- methyl-1H-indolizino(8,1-cd)carbazole-5-carboxylate, sulfate salt; Nincaluicolflastine sulfate; Vincaleukoblastine sulfate salt;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 267 C  (Decomposes)
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER 10 mg/ml
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

Health: 2, Flammability: 1, Reactivity: 0

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Vinca alkaloids, including the natural products vincristine and vinblastine and the semisynthetic derivatives vindesine and vinorelbine, are antimitotic drugs that are widely used in the retreatment of cancer. Vinorelbine, a microtubule inhibitor, is the latest of the Vinca alkaloids, which promotes apoptosis in several tumor cell lines and in vitro shows both multidrug and non-multidrug resistance. Vinorelbine induce disassociation of cellular microtubules, most likely by modifying the dynamics of the spindle microtubules. This suppression of microtubule dynamics appears to cause a mitotic block by activating the metaphase-anaphase checkpoint. Vinorelbine arrests cell cycle and inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. Microtubules are present in mitotic spindles, neuronal axons, and other cells. Inhibition of mitotic microtubules appears to correlate with antitumor activity, while inhibition of axonal microtubules seems to correlate with neurotoxicity. Compared to vincristine and vinblastine, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. Like the other Vinca alkaloids, vinorelbine has a potency in the submicromolar range.(source: Sigma-Aldrich)

Mitotic inhibitors are often plant alkaloids and other compounds derived from natural products. They can stop mitosis or inhibit enzymes from making proteins needed for cell reproduction. These work during the M phase of the cell cycle but can damage cells in all phases. They are used to treat many different types of cancer including breast, lung, myelomas, lymphomas, and leukemias. These drugs are known for their potential to cause peripheral nerve damage, which can be a dose-limiting side effect. (source: American Cancer Society)

Mitotic Inhibitors

Product

CAS RN.

Vincristine

57-22-7
Colchicine 64-86-8
2-Methoxyestradiol 362-07-2
Demecolcine 477-30-5
Podofilox 518-28-5
Vinblastine 865-21-4
Trifluralin 1582-09-8
Estramustine 2998-57-4
Benomyl 17804-35-2
Oryzalin 19044-88-3

Teniposide

29767-20-2
Nocodazole 31430-18-9
Mebendazole 31431-39-7
Paclitaxel 33069-62-4
Etoposide 33419-42-0
Maytansine 35846-53-8
Vindesine 53643-48-4
Albendazole 54965-21-8
Phomopsin A 64925-80-0
Ansamitocins 69279-90-9
Vinorelbine 71486-22-1
Combretastatin 82855-09-2
Rhizoxin 90996-54-6
Dolastatin 10 110417-88-4
Cryptophycin 124689-65-2
Disermolide 127943-53-7
Docetaxel 148408-66-6
Epothilone B 152044-54-7
Ixabepilone 219989-84-1
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

ASSAY

96.0 - 102.0% (on dried basis)

ETHYL ALCOHOL

15.0% max

ACETONE

0.1% max
pH 3.5 - 5.0 (0.15% Solution)

HEAVY METALS

20ppm max
LOSS ON DRYING

15.0% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols:XN , Risk Phrases:22-37/38-41 , Safety Phrases: 26-36/39
PRICE INFORMATION

Click to open the table