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WITHAFERIN A |
| Synonyms. Withaferin A; (4beta,5beta,6beta,22R)-5,6-Epoxy-4,22,27-trihydroxy-1- oxoergosta-2,24- dien- 26-oic acid delta-lactone; (20S,22R)-5,6-beta-Epoxy-4- beta,22,27-trihydroxy-1-oxo-5-beta- ergosta -2,24-dien-26- oic acid delta-lactone; (4bta,5beta,6beta,22R)- 5,6-Epoxy-4,22,27- trihydroxy- 1-oxo-ergosta-2,24-dien-26-oic acid gamma-lactone; 5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24 -dienolide; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
5119-48-2 |
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EINECS RN |
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FORMULA |
C28H38O6 |
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MOLE WEIGHT |
470.60 |
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H.S CODE |
2932.20.2000 |
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SMILES |
O1[C@@]23[C@@]([C@@H]4[C@@H]([C@@H]5[C@@] ([C@@H]([C@H] ([C@ @H](CC6=C(C(=O)OC6)C)O)C)CC5) (C)CC4)C[C@@H]12)(C(C= C[C@@ H]3O )=O)C |
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CLASSIFICATION |
Angiogenesis Inhibitor. Ergosterol analog |
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EXTRA NOTES |
Withaferin A is a steroidal lactone that is isolated from the plant Withania somnifera. It has potent anti-inflammatory properties as it inhibits the activation of NF-κ B signaling pathway. The anti-tumor activity of Withaferin A is due to its ability to alter cytoskeletal architecture by binding annexin II and disrupting F actin cross-links. Withaferin A also inhibits angiogenesis by binding to vimentin and F-actin (sigmaaldrich) |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
White to off-white crystalline powder |
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MELTING POINT |
241 ~ 245 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY | DMSO, Ethanol |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pH |
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REFRACTIVE INDEX |
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FLASH POINT |
226 C |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong acids and oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 0, Flammability: 1, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Withaferin A Google Scholar Search - Withaferin A Drug Information Portal (U.S. National Library of Medicine) - Withaferin A PubChem Compound Summary - Withaferin A KEGG (Kyoto Encyclopedia of Genes and Genomes) - Withaferin A Chemical Entities of Biological Interest (ChEBI) - Withaferin A http://www.ncbi.nlm.nih.gov/ - Withaferin A Human Metabolome Database - Withaferin A |
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| SALES SPECIFICATION | |
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APPEARANCE |
White to off-white crystalline powder |
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PURUTY |
98.0% min (HPLC) |
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MELTING POINT |
241 ~ 245 C |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
OSHA Hazards: No known hazards. Eyes: May cause eye irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Ingestion: May be harmful if swallowed. |
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GHS |
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SIGNAL WORD |
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PICTOGRAMS |
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HAZARD STATEMENTS |
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P STATEMENTS |
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| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
68 |
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SAFETY PHRASES |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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| PRICE INFORMATION |
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