alpha-AMYRIN

PRODUCT IDENTIFICATION
CAS NO.

638-95-9

AMYRIN
EINECS NO. 211-352-1
FORMULA C30H50O
MOL WT. 426.72

H.S. CODE

  

TOXICITY

 
SYNONYMS Viminalol; alpha-Amyrenol; alpha-Amyrine;
Urs-12-en-3beta-ol; (3beta)-Urs-12-en-3-ol; (3S,4aR,6aR,6bS,8aR,11R,12S,12aR, 14aR,14bR)- 4,4,6a,6b,8a,11,12,14b- Octamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a, 14,14a-tetradecahydro-1H- picen-3-ol;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 188 C
BOILING POINT 243 C
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  

SOLVENT SOLUBILITY

 Soluble in ether, benzene, chloroform, glacial acetic acid
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Amyrins are abundant naturally occurring two isomeric pentacyclic triterpenes. Alpha-amyrin has the 29-carbon at the 20 position. Beta-amyrin has the 29-carbon shifted to the 19 position. Amyrins occur mostly as acetate in latex of rubber trees. They are considered they have broad-spectrum analgesic properties.

Alpha-Amyrin is a precursor of Ursolic acid that is obtained by converting the CH3 in 28 to COOH. Beta Amyrin is a precursor of Boswellic acid that is obtained by converting the CH3 in 24 to COOH. Ursolic acid has anti elastase activity, and like cholesterol, modulates the membrane fluidity. It prevents UV-B irradiation damages to the skin through prevention of lipid peroxidation and PGE2 release inhibition. Boswellic acid is a strong 5-lipoxigenase inhibitor and it has also anti elastase and anti GAGase properties. Alpha Amyrin has strong anti-inflammatory activity, is a PKA inhibitor as well as a selective protease inhibitor: chymotrypsin is inhibited at an 18-micromolar level (source: www.naturactiva.net/)
SALES SPECIFICATION

APPEARANCE

 white crystalline powder
CONTENT

98.0% min
LOSS ON DRYING

1.0% max

ASH

0.1% max

OPTICAL ROTATION

 +91° ~ +92° (c = 1.3 in benzene)

HEAVY METALS

10ppm max

RESIDUE ON IGNITION

0.1% max
RELATED SUBSTANCE 2.0% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36, Safety Phrases: 22-24/25