alpha-NAPHTHOFLAVONE

alpha-NAPHTHOFLAVONE

alpha-Naphthoflavone; 2-Phenyl-4H-naphtho(1,2-b)pyran-4-one; 7,8-BF; 7,8-Benzoflavone; Benzo(h)flavone; alpha-Naphthylflavone; ANF; ,2-Phenylbenzo[H]chromen-4-one;

PRODUCT IDENTIFICATION
CAS RN	604-59-1
EINECS RN	210-071-1
FORMULA	C₁₉H₁₂O₂
MOLE WEIGHT	272.30
H.S. CODE	2932.99.6100
UN NO.
SMILES	c12c3c(ccc1c(cc(o2)c1ccccc1)=O)cccc3
CLASSIFICATION	Benzopyrans, Indicator (Redox, Titration), Antioxidant, Flavonoid
EXTRA NOTES	Inhibitor of aryl hydrocarbon hydroxylase and chemical carcinogenicity.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	slightly yellow powder.
MELTING POINT	155 - 158 C
BOILING POINT
DENSITY
SOLUBILITY IN WATER	Insoluble
SOLVENT SOLUBILITY	Slightly soluble in ethanol, chloroform. Soluble in sulfuric acid
pH
VAPOR DENSITY
REFRACTIVE INDEX
FLASH POINT

STABILITY AND REACTIVITY
STABILITY	Stable under normal conditions
INCOMPATIBILITIES	Strong oxidizing agents
DECOMPOSITION PRODUCTS	Carbon oxides\
POLYMERIZATION
NFPA RATING	Health: 1; Flammability: 0; Instability: 0;
TOXICOLOGICAL

POTENTIAL HEALTH EFFECTS
HAZARD OVERVIEW	May cause eye and skin irritation. May cause respiratory and digestive tract irritation.
EYE	May cause eye irritation.
SKIN	May be harmful if absorbed through skin. May cause skin irritation.
INGESTION	May cause irritation of the digestive tract.
INHALATION	May be harmful if inhaled. May cause respiratory tract irritation.
TARGET ORGANS	No data found.

TRANSPORT & REGULATORY INFORMATION
UN NO.
HAZARD CLASS
PACKING GROUP
HAZARD SYMBOL
RISK PHRASES
SAFETY PHRASES	24/25

EXTERNAL LINKS & GENERAL INFORMATION

Wikipedia Linking

Material Safety Data Sheet

Google Scholar Search

http://www.sciencemag.org/
Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats.

http://pubs.acs.org/
The aim of this study was to systematically examine the inhibitory mechanisms of the flavonoid α-naphthoflavone (α-NF) in platelet activation. In this study, α-NF concentration dependently (5−20 μM) inhibited platelet aggregation stimulated by agonists. α-NF (5 and 10 μM) inhibited intracellular Ca²⁺ mobilization, phosphoinositide breakdown, and thromboxane A₂ formation stimulated by collagen (1 μg/mL) in human platelets. In addition, α-NF (5 and 10 μM) markedly increased levels of cyclic GMP and cyclic GMP-induced vasodilator-stimulated phosphoprotein (VASP) Ser¹⁵⁷ phosphorylation. Rapid phosphorylation of a platelet protein of Mr 47 000 (P47), a marker of protein kinase C activation, was triggered by phorbol-12,13-dibutyrate (60 nM).

SALES SPECIFICATION
APPEARANCE	white to light yellow crystalline powder
CONTENT	95% min
MELTING POINT	155 - 158 C

PRICE

U$1,400.- (1kg)