3,4-DIMETHOXYANILINE

PRODUCT IDENTIFICATION

CAS NO. 6315-89-5

3,4-DIMETHOXYANILINE

EINECS NO. 228-647-6
FORMULA (CH3O)2C6H3NH2
MOL WT. 153.18
H.S. CODE  
TOXICITY  
SYNONYMS 1,2-Dimethoxy-4-aminobenzene; 4-Aminoveratrole;
3,4-Dimetoxianilina; 3,4-Diméthoxyaniline;
SMILES
 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

off-white to gray powder

MELTING POINT 87 - 88 C
BOILING POINT 174 - 176 C at 22 mm Hg
SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Soluble
AUTOIGNITION

 

pH  
VAPOR DENSITY  
NFPA RATINGS Health: 2; Flammability: 1; Reactivity: 0
REFRACTIVE INDEX  
FLASH POINT > 110 C
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Ether is any of a number of organic compounds characterized by an oxygen atom joined with single bonds by two carbon atoms that are part of hydrocarbon groups. The general formula is R-O-R', where R and R' are alkyl or aromatic groups. Ethers are formed by the condensation of two alcohols by heating with sulfuric acid; the reaction is one of dehydration. Ethers can be prepared from alkyl halide reacted with metallic alkoxide (called Williamson synthesis). Ethers are similar to alcohols but are generally less dense, less soluble in water, and have lower boiling points. They are relatively unreactive, which makes them valuable solvents. But ethers will be cleaved at high temperatures by concentrated hydrogen halides. Ethers have relatively low boiling point compare to alkanes as they don't form hydrogen bonds each other. Ethers are more lipophilic than esters [R-C(=O)-O-R']or amides [RCO-NH2]. Ethers are widely used as solvents for various organic reactions because they are relatively the least reactive among common organic compounds except alkanes and fluorocarbons. The common reaction of ethers is cleavage of the C–O bond by strong acids either in linear chain or cyclic structure. Ethers in which oxygen is bonded to primary and secondary alkyl groups can form peroxide compounds in the presence of gaseous oxygen due to two unpaired electrons in oxygen. Ethers can act as Lewis bases in chemical reactions. Commonly, ethers are named simply in listing the alkyl groups in alphabetical order or alkane order such as ethyl methyl ether or methyl ethyl ether, which is methoxyethane in IUPAC nomenclature ( the formula of "alkoxyalkane" ). When ether is a parts of complex molecule or aromatic derivatives, it is described as an alkoxy substituent such as methoxybenzene ( trivial name is anisole). The methoxy prefix indicates the function methyl group joined by single bonds to an oxygen atom, with the general formula  -O-CH3. Cyclic ethers have ring structure where the oxygen has become part of the ring. The term of epoxide indicate three membered cyclic ether (also called oxirane) in which an oxygen atom is joined to each of two carbon atoms that are already bonded to each other; four membered cyclic ether is called oxetane; five membered cyclic ether, furan (or oxolane); six membered cyclic ether, pyran (also called oxane) respectively. Their unhindered oxygen atom carries two unshared pairs of electrons - a structure which favors the formation of coordination complexes and the solvation of cations. Cyclic ethers are used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. Crown Ether is a macrocyclic polyether whose structure contains hydrogen, carbon and oxygen atoms. Each oxygen atoms are confined between two carbon atoms and exhibits a conformation with a hole (accordingly called "crown").  Anisole is one of the simplest aromatic compound to which ether group is linked. But it is different with aromatic compounds like furan where the oxygen is a part of the ring.  Anisole, C6H5OCH3 (methyl phenyl ether), is a clear liquid that is soluble in ether and alcohol; insoluble in water; boiling point 155 C. Anisole and its derivatives are used as solvents and in perfumery. Anisole can be obtained from anise seed. Anisic acid, p-methoxybenzoic acid, is a part of cresol class antiseptic compounds. It is also used as an insect repellent and ovicide. Anisole, anisic acid, and their derivatives are also widely used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.

Benzoic acid derivatives substituted by hydroxy group or ether containing oxygen atom have active bacteriostatic and  fragrant properties. They are typically used in pharmaceutical and perfumery industry. The destructive metabolic property of oxygen containing benzoic acid derivatives such as protocatechuic acid (3,4-dihydroxybenzoic acid) and veratric acid (3,4-dimethoxybenzoic acid) is used in the application for pharmaceuticals. Protocatechuic acid is a catabolite of epinephrine. Prazosin, a peripheral vasodilator and antihypertensive, is also an example of the applicaion of veratric acid. Hydroxy and ether substituted benzoic acids feature analogue metabolite of aspirin (acetylsalicylic Acid). They are used as intermediates for pharmaceuticals (especially for antipyetic anlgesic, antirheumatism) and other organic synthesis. They are used as matrix for ionization of peptides, proteins and carbohydrates.

Guaiacol is the methyl ether of pyrocatechol. It is a main constituent of creosote obtained from wood tar (mainly beech) by distillation mostly between 203 and 220 C. It is synthesized from anisole also. The dimethyl ether of pyrocatechol is called veratrol. They and their derivatives are used as an external antiseptic, expectorant, gastric sedative, deodorant, and as a parasiticide. Methoxyphenols are used in manufacturing stabilizers and antioxidants for plastics and rubbers. They are also used in analgesics, local anesthetic, flavorings, biocides, antiseptics. 2-Methoxyphenol is used in manufacturing vanillin and other flavorings. Dimethoxyanilines are used as an intermediate for dyes, pigments and pharmaceuticals.

SALES SPECIFICATION

APPEARANCE

off-white to gray powder

CONTENT

98.0% min

MELTING POINT 87 - 88 C
TRANSPORTATION
PACKING 25kgs in bag
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 28A/37/45