3-(ETHOXYCARBONYL)-1-PHENYL-5-PYRAZOLONE

PRODUCT IDENTIFICATION
CAS NO. 89-33-8

3-(ETHOXYCARBONYL)-1-PHENYL-5-PYRAZOLONE
EINECS  NO. 201-899-4
FORMULA C12H12N2O3
MOL WT. 232.24
H.S. CODE  
TOXICITY

 
SYNONYMS Ethyl 5-oxo-1-phenyl-2-pyrazoline-3-carboxylate;
1-Fenil-5-oxo-2-pirazolina-3-carboxilato de etilo; 5-Oxo-1-phényl-2-pyrazoline-3-carboxylate d'éthyle; 1-Phenyl-3-carbethoxypyrazolone; 4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H- pyrazole-3-carboxylic acid, ethyl ester; Ethyl 1-phenyl-5-pyrazolinone-3-carboxylate;
SMILES 
 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

yellow to brown crystalline powder
MELTING POINT

252 C (Decomposes)
BOILING POINT

 
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY  
AUTOIGNITION

 
NFPA RATINGS Health: 2; Flammability: ; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY Stable under ordinary conditions.

APPLICATIONS
Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders.

The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents.  Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine.

Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 4-Aminoantipyrine possibly can be used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs. It is also used in the colorimetric determination of phenols.

Amidopyrine is used in manufacturing drugs especially for antipyretic, analgesic, antirheumatic and sedative agent agents. This substance has analgesic, anti-inflammatory, and antipyretic properties. But the use is discouraged due to the risk of agranulocytosis.

Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 3-(Ethoxycarbonyl)-1-phenyl-5-pyrazolone is used as an intermediate to prepare dyes and pigments.
SALES SPECIFICATION

APPEARANCE

yellow to brown crystalline powder
ASSAY

95.0% min (Dry purity)
WATER

5.0% max
TRANSPORTATION
PACKING  
HAZARD CLASS 8 (Packing Group: II)
UN NO. 3261
OTHER INFORMATION
Hazard Symbols: S, Risk Phrases: 34, Safety Phrases: 26-36/36/39-45