CYCLOHEXANECARBOXYLIC ACID CHLORIDE

CYCLOHEXANECARBOXYLIC ACID CHLORIDE
PRODUCT IDENTIFICATION
CAS NO.	2719-27-9
EINECS NO.	220-322-7
FORMULA	C₇H₁₁COCl
MOL WT.	146.62
H.S. CODE
TOXICITY
SYNONYMS	Chlorocarbonylcyclohexane; Cyclohexanoyl chloride;
Cyclohexanecarboxylic acid chloride; Hexahydrobenzoyl chloride;
SMILES
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	clear to yellow liquid
MELTING POINT	29 C
BOILING POINT	184 C
SPECIFIC GRAVITY	1.096
SOLUBILITY IN WATER	hydrolyses
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health: 3; Flammability: 1; Reactivity: 0
REFRACTIVE INDEX	1.468 - 1.470
FLASH POINT	66 C
STABILITY	Stable under ordinary conditions. Moisture sensitive.
GENERAL DESCRIPTION & APPLICATIONS
Acyl is a radical formed from an organic acid by removal of a hydroxyl group. The general formula of acyl compound is RCO-. Acyl halide is one of a large group of organic substances containing the halocarbonyl group, have the general formula RCO·X, where R may be aliphatic, alicyclic, or aromatic and halide is any compound of halogens (fluorine, chlorine, bromine, iodine, and astatine) with another elements and groups. In substitutive chemical nomenclature, their names are formed by adding '-oyl' as a suffix to the name of the parent compound; ethanoyl chloride, CH₃COCl, is an example. The terms acyl and aroyl halides refer to aliphatic or aromatic derivatives, respectively. Acyl halides are made by replacing the -OH group in carboxylic acids by halogen using halogenating agents. They react readily with water, alcohols, and amines and are widely used in organic synthetic process whereby the acyl group is incorporated into the target molecules by substitution of addition-elimination sequence called acylation reaction. Acylation reaction involves substitution by an electron donor (nucleophile) at the electrophilic carbonyl group (C=O). Common nucleophiles in the acylation reaction are aliphatic and aromatic alcohols, both of which give rise to esters and amines (RNH₂) which give amides. The carboxylic acid (X = OH) itself can function as an acylating agent when it is protonated by a strong acid catalyst as in the direct esterification of an alcohol. Two common acylation agents, with the general formula RCOX, are acid halides (X = halogen atom) and anhydrides (X = OCOR). Schotten-Baumann reaction is an acylation reaction that uses an acid chloride in the presence of dilute alkali to acylate the hydroxyl and amino group of organic compounds. There are also other acylating agents. Acyl halide compounds are used as an intermediate for agrochemicals and pharmaceuticals, dyes, and peroxide compounds as well as textile auxiliaries, emulsifiers.
SALES SPECIFICATION
APPEARANCE	clear to yellow liquid
CONTENT	98.0% min
TRANSPORTATION
PACKING
HAZARD CLASS	8 (Packing Group: III)
UN NO.	3265
OTHER INFORMATION
`Hazard Symbols: C, Risk Phrases: 34`, `Safety Phrases:` 25-36/37/39-45
GENERAL DESCRIPTION OF CYCLOHEXANE
Cyclohexane is the six-membered alicyclic hydrocarbon consisting of six carbon atoms linked to each other to form a ring, with each carbon atom bearing two hydrogen atoms, C6H12. A cyclic compound is an organic compound that contains one or more closed rings of carbon atoms. The term alicyclic refers to cyclic compound that behaves chemically like aliphatic compounds (open-chain), which means the exclusion of carbocyclic compounds of aromatic rings with an array of π-electrons characteristic. Cyclohexane is a colorless, highly flammable, mobile liquid with a pungent odor. It is insoluble in water and soluble in alcohol, ether, and almost organic solvents. Cyclohexane is a non-corrosive and quick volatilize liquid and sublimes between -5 to 5 C. Cyclohexane can exist in a number of interconvertible three-dimensional conformations, the two simplest being are the chair and boat conformation and others include the half-chair and twist-chair conformation. Cyclohexane can cause irritation to the eyes and mucous membranes in workers. Repeated and prolonged contact with skin may cause dermatitis. The substance has not been shown to cause the hematologic changes associated with exposure to benzene. Cyclohexane occurs naturally in crude oils. Some cyclohexane is recovered from petroleum streams by fractionation. The bulky commercial production of cyclohexane is based on hydrogenation of benzene in closed system. Cyclohexane consumption is linked almost entirely to nylon production. Nylon is further processed into fibers for applications in carpeting, automobile tire cord, clothing, and other growing industrial fields. Cyclohexane is used as a solvent, oil extractant, paint and varnish remover, dry cleaning material, and in solid fuels. It has been used as a insecticide itself. Cyclohexane is used as a chemical intermediate to produce target molecules. Natural compounds of one to five alicyclic rings with great variety and complexity are found particularly in steroids and terpenes. Cyclohexane structure, six membered-ring, is one of the major skeleton in nature. Cyclohexane derivatives can be used for the synthesis of pharmaceuticals, dyes, herbicides, plant growth regulator, plasticizers, rubber chemicals, cycloamines and other organic compounds.
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