PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
1-[4-(2- Hydroxyethylsulfonyl)phenyl]-3-methyl-5-pyrazolone;
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT
SOLUBILITY IN WATER
REFRACTIVE INDEX
APPLICATIONS
The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents. Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine.
Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 4-Aminoantipyrine possibly can be used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs. It is also used in the colorimetric determination of phenols.
Amidopyrine is used in manufacturing drugs especially for antipyretic, analgesic, antirheumatic and sedative agent agents. This substance has analgesic, anti-inflammatory, and antipyretic properties. But the use is discouraged due to the risk of agranulocytosis.
Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 2,4-Dihydro-2-[-4-[(2-hydroxyethyl) sulfonyl] phenyl]-5-methyl-3H-pyrazol-3-one is used as an intermediate for colorants.
Organosulfur compounds are widely used in refineries, steamcrackers, aromatic extraction and petrochemical manufacturing as they acts as hydrotreating catalysts, initial catalyst improvers, sulfur source and catalyst presulfiding. Sulfoxide (R2SO) is any of various organic sulfur compounds having the group -SO (sulfinyl group) whereas sulfone (RSOOR) with the group -SO2 (sulfonyl group). They are derived from oxidation of sulfides. The common examples of sulfone compounds are dapsone (4,4'-sulfonylbisbenzenamine) and its derivative. Dapsone (4,4'-sulfonylbisbenzenamine) is a parent compound in preparing sulfonamide antibacterial agents such as acedapsone, acetosulfone, glucosulfone, sulfoxone and solapsone. Dapsone and its derivatives have bacteriostatic activity against a broad spectrum of gram-negative and gram-positive organisms. Dapsone is a primary treatment for Dermatitis herpetiformis and in the treatment of leprosy (Mycobacterium leprae infections) leads to apparent improvementas. It is used in the prophylaxis of falciparum malaria. It is a white crystalline powder; melting point 175 - 180C; insoluble in water and vegetable oils. Dapsone is also widely used in polymer industry as a cross linkage agent in manufacturing polysulfone amide engineering plastics. Sulfone-containing engineering plastics are thermally stable and have high resistance property to acids and alkalis. Tazobactam is a penicillanic acid sulfone derivative which acts as a beta-lactamase inhibitor similar to sulbactam. Tazobactam is used in combination with piperacillin to widen the spectrum of activity. Sulfone class compounds which have a sulfonyl group attached to two carbon atoms are active as an antibiotic.
APPEARANCE
WATER