1-(3-CHLOROPHENYL)-3-METHYL-2-PYRAZOLIN-5-ONE

PRODUCT IDENTIFICATION
CAS NO. 90-31-3

1-(3-CHLOROPHENYL)-3-METHYL-2-PYRAZOLIN-5-ONE
EINECS  NO. 201-984-6
FORMULA C10H9ClN2O
MOL WT. 208.64
H.S. CODE  
TOXICITY

 
SYNONYMS 2-(3-chlorophenyl)-2,4-dihydro-5-methyl-3H-pyrazol-3-one;
2-(3-clorofenil)-2,4-dihidro-5-metil-3H-pirazol-3-ona;
SMILES 
 

CLASSIFICATION

PYRAZOLONES /

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

yellow to beige powder
MELTING POINT

128 - 131 C
BOILING POINT

 
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY  
AUTOIGNITION

 
NFPA RATINGS Health: 2; Flammability: ; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY Stable under ordinary conditions.

APPLICATIONS
Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders.

The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents.  Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine.

Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 4-Aminoantipyrine possibly can be used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs. It is also used in the colorimetric determination of phenols.

Amidopyrine is used in manufacturing drugs especially for antipyretic, analgesic, antirheumatic and sedative agent agents. This substance has analgesic, anti-inflammatory, and antipyretic properties. But the use is discouraged due to the risk of agranulocytosis.

Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one is used as an intermediate to prepare dyes and pigments.
SALES SPECIFICATION

APPEARANCE

yellowish crystalline powder
ASSAY

98.0% min
WATER

0.5% max
TRANSPORTATION
PACKING 25kgs in fiber drum
HAZARD CLASS 8 (Packing Group: II)
UN NO. 3261
OTHER INFORMATION
Hazard Symbols: S, Risk Phrases: 34, Safety Phrases: 26-36/36/39-45