QUINAZOLINE

PRODUCT IDENTIFICATION
CAS NO. 253-82-7

QUINAZOLINE
EINECS NO. 205-965-3
FORMULA C8H6N2
MOL WT. 130.15
H.S. CODE  
TOXICITY  
SYNONYMS

5,6-Benzopyrimidine; Penmiazine; 1,3-Benzodiazine;

Benzo[alpha]pyrimidine; Chinazolin; Quinazolina;

SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE light yellow crystals
MELTING POINT 48 - 49 C
BOILING POINT 243 C
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 Health: 0; Flammability: 1; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

106 C
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Quinoline, 1-azanaphthalene, is an aromatic nitrogen compound characterized by a solid-ring structure contains a benzene fused to pyridine at two adjacent carbon atoms. (Pyridine is a ring structure compound of five carbon atoms with a nitrogen atom). Quinoline itself is the simplest member of the quinoline. It is a hygroscopic, yellowish oily liquid; slightly soluble in water, soluble alcohol, ether, carbon disulfide and readily in many organic solvents. It can be obtained by the distillation of coal tar. Quinoline can be prepared from aniline with acrolein under heated sulfuric acid (Skraup synthesis). Various quinoline compounds can be prepared by Skraup synthesis series of different oxidizing agents. Isoquinoline differs from quinoline in nitrogen position (at 2).

Quinoline family compounds are widely used as a parent compound to make drugs (especially anti-malarial medicines), fungicides, biocides, alkaloids, dyes, rubber chemicals and flavoring agents. They have antiseptic, antipyretic, and antiperiodic properties. They are also used as catalyst, corrosion inhibitor, preservative, and as solvent for resins and terpenes. They are used in transition-metal complex catalyst chemistry for uniform polymerization and luminescence chemistry. They are used as antifoaming agent in refinery field. Quinaldine, 2-methylquinoline, is used as an anti-malaria and preparing other anti-malaria drugs. It is used in manufacturing oil soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Quinaldic Acid is a carboxylic acid substituted quinoline at 2 position, a catabolite of tryptophan (aromatic side chain amino acid).

Quinazoline is a heterocyclic solid-ring structure compound containing a benzene fused to pyrimidine. There are four isomers which are identified by Nirtogen positions; Cinnoline (1,2-Benzodiazine; Benzo[c]pyridazine; 1,2-Diazanaphthalene, CAS #: 253-66-7), Phthalazine (2,3-Benzodiazine; Benzo[d]pyridazine, CAS #: 253-52-1), Quinazoline (1,3-Benzodiazine; Benzo[a]pyrimidine, CAS #: 253-82-7), and Quinoxaline (1,4-Benzodiazine; Benzo[a]pyrazine, CAS #: 91-19-0). They have bicyclic aromatic ring structures comprising a benzene ring linked to two-nitrogen containing aromatic ring such as pyridazine, pyrimidine, pyrazine. Examples of end products which have the fundamental structures of them are:
  • Cinnoline structure
    • Cintazone (non-steroidal anti-inflammatory agent)
    • Cinoxacin (quinolone class anti-infective agent)
  • Phthalazine structure
    • Hydralazine, Todralazine (Antihypertensives)
  • Quinazoline structure
    • Prazosin and Doxazosin (Adrenergic alpha-antagonists)
  • Quinoxaline structure
    • Sulfaquinoxaline (Anti-infective agent or Antiprotozoal agent)
    • Echinomycin (polypeptide antibiotic agent)

Diazanaphthalenes and their derivatives are used for making medicines such as anthelmintic, antiallergenic, anti-histamic, anti-emetic and anti-migraine agents. They are used as chemical intermediates for making fungicides and other organic compounds.

Luminol, a chemoluminescent dye, is a phthalazinedione derivative. Diazanaphthalenes can find applicaton in the luminescence (light emission), generated as the result of direct transformation of chemical energy into light energy without showing a corresponding degree of heat. Diazanaphthalenes can be the basic substance of fluorescent properties, used in luminescence chemistry of photosensitizing and organic electroluminescence materials industry which lead to the rapid development of photovoltaic and display devices.

SALES SPECIFICATION

APPEARANCE

 light yellow crystals
CONTENT

99.0% min
TRANSPORTATION
PACKING 25kg sin fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 24/25