ASIATICOSIDE

Madecassol; (O-alpha-L-Rhamnopyranoxyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D- glucopyranosyl)- 2alpha,3beta,23-trihydroxy-12-ursen-28-oat; 2alpha,3beta,23-Trihydroxy-urs- 12-en-28-saeure(O-alpha-L- rhamnopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta- D-glucopyranosyl)ester; Asiaticosid; Blastoestimulina; Centelase; Dermatologico; Emdecassol; O-6-Desoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl 2alpha,3beta,23-trihydroxy-12-ursen-28-at;

PRODUCT IDENTIFICATION

CAS RN

16830-15-2

EINECS RN

240-851-7

FORMULA

MOLE WEIGHT

CHEMICAL FAMILY

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

White to off-white powder

MELTING POINT

BOILING POINT

DENSITY

SOLUBILITY IN WATER

pH

VAPOR DENSITY

REFRACTIVE INDEX

FLASH POINT

INCOMPATIBLE MATERIALS

Strong oxidizing agents

Carbon oxides

TOXICOLOGICAL

SAFETY

HAZARD NOTES

EYE

May cause eye irritation. In case of eye contact, flush eyes with water as a precaution.

SKIN

May be harmful if absorbed through skin. In case of skin contact, wash off with soap and plenty of water.

INGESTION

May be harmful if swallowed. Never give anything by mouth to an unconscious person. Rinse mouth with water.

INHALATION

May be harmful if inhaled. May cause respiratory tract irritation. If breathed in, move person into fresh air. If not breathing give artificial respiration.

TARGET ORGANS

CHRONIC

TRANSPORT & REGULATORY INFORMATION

UN NO.

HAZARD SYMBOL

RISK PHRASES

SAFETY PHRASES

Wikipedia Linking: http://en.wikipedia.org/wiki/Scartini_scar_cream

Centella asiatica (Linn) Urban known as Indian pennywort is a prostate, perennial, faintly aromatic herb found wild throughout India]. Leaves are used as tonic, memory enhancer and also used in the treatment of cataract, eye troubles and in fevers and diarrhea among children. The plant is reported to contain glycosides like brahmosides, indocentelloside, asiaticoside, theankuniside and isotheankuniside. Asiaticoside, a trisaccharide triterpene, has been identified as the most active compound in the plant associated with the healing of wounds and duodenal ulcers, whilst the triterpene saponins are also reported to possess immunomodulatory properties. Asiaticoside is one of the most active compounds which can serve as a marker and is used for its standardization. A few methods such as gravimetric and column chromatography have been suggested for the quantitative estimation of asiaticoside which are not very precise, sensitive and require multiple step extraction and purification. (http://www.science.cmu.ac.th/)

Interestingly, asiaticoside was shown to inhibit healing of experimental corneal wounds in rabbits (Callizo et al. 1996). Studies of the effect of asiaticoside in corneal wounds and ulcers have been documented by Abou Shousa & Khalil (1967) and by Mekkawi (1968). Asiaticoside appears also to be able to inhibit collagen production in such a way as to inhibit formation of hypertrophic scars, keloids, and stretch marks (striae gravidarum / striae distensae) (Bosse et al. 1979, Qi et al. 2000, Widgerow et al. 2000, Young & Jewell 2003). Extracts from the plant have been formulated into several commercial products including Collaven™, Emdecassol™, Madecassol™, Centelase™, Marticassol™, Blastoestimulina™, and Trofolastin™. Reports of allergic contact dermatitis, confirmed by patch testing have appeared sporadically following topical use of Madecassol™, (Eun & Lee 1985), Centelase™ (Santucci et al. 1985, Vena & Angelini 1986, Danese et al. 1994), and Blastoestimulina™ (Izu et al. 1992, Aguirre et al. 1993, Bilbao et al. 1995, Gonzalo Garijo et al. 1996). Asiaticoside, asiatic acid, and madecassic acid appear to be the sensitisers (Huriez & Martin 1969, Hausen 1993). The possibility of sensitivity to other components of the formulations (for example, propylene glycol) should not be overlooked (Eun & Lee 1985, Hausen 1993). (http://botanical-dermatology-database.info/)

 The pharmacological activity of Centella asiatica is thought to be due to several saponin constituents, including asiaticoside, asiatic acid, and madecassic acid. In vitro, each of these compounds stimulated the production of human collagen I, a protein involved in wound healing. Stimulation of collagen synthesis in foreskin fibroblast monolayer cultures by an extract from Herba Centellae has also been reported. Asiaticoside accelerated the healing of superficial postsurgical wounds and ulcers by accelerating cicatricial action. Asiaticoside stimulates the epidermis by activating the cells of the malpighian layer in porcine skin, and by keratinization in vitro. Topical application of asiaticoside promoted wound healing in rats and significantly increased the tensile strength of newly formed skin. Extracts of C. asiatica, and in particular its major triterpene ester glycoside, asiaticoside, are valuable in the treatment of hypertrophic scars and keloids. Asiaticoside has been reported to decrease fibrosis in wounds, thus preventing new scar formation. The mechanism of action appears to be twofold: by increasing the synthesis of collagen and acidic mucopolysaccharides, and by inhibiting the inflammatory phase of hypertrophic scars and keloids. It has further been proposed that asiaticoside interferes with scar formation by increasing the activity of myofibroblasts and immature collagen. (http://www.zeamais.com/)

SALES SPECIFICATION

APPEARANCE

pass (TLC)

CONTENT

80.0% min (Asiaticoside)

LOSS ON DRYING

3.0% max

5ppm max

0.2ppm max

0.3ppm max

2ppm max

0,02ppm max

1.0% max

100 mesh (95%)x

PRICE INFORMATION