|
CALCIPOTRIENE |
| (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol; Calcipotriol; (1alpha,3beta,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19), 22-tetraene-1alpha,3beta,24-triol; Daivonex; Dovonex; Psorcutan; |
|
|
| \PRODUCT IDENTIFICATION |
|
|
CAS RN |
112965-21-6; 112828-00-9 |
|
EINECS RN |
|
|
FORMULA |
C27H40O3 |
|
MOLE WEIGHT |
412.60 |
|
CHEMICAL FAMILY |
Derivative of Vitamin D |
| CATEGORIES | Antipsoriatic |
|
|
| PHYSICAL AND CHEMICAL PROPERTIES |
|
|
PHYSICAL STATE |
white to off-white crystalline powder |
|
MELTING POINT |
|
|
BOILING POINT |
|
|
DENSITY |
|
|
SOLUBILITY IN WATER |
(DMSO: 24mg/ml) |
|
pH |
|
|
VAPOR DENSITY |
|
|
REFRACTIVE INDEX |
|
|
FLASH POINT |
|
|
|
| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
|
INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| DECOMPOSITION PRODUCTS |
Carbon oxides |
| POLYMERIZATION | Has not been reported |
|
TOXICOLOGICAL |
LD50 Dermal - rat: > 15 mg/kg |
|
|
| SAFETY |
|
|
HAZARD NOTES |
Danger. Fatal in contact with skin. |
|
EYE |
Causes serious eye irritation. |
|
SKIN |
Harmful if absorbed through skin. Causes skin irritation. |
|
INGESTION |
May be harmful if swallowed. |
|
INHALATION |
May be harmful if inhaled. Causes respiratory tract irritation. |
|
TARGET ORGANS |
|
|
CHRONIC |
|
|
|
| TRANSPORT & REGULATORY INFORMATION |
|
|
UN NO. |
|
| HAZARD CLASS |
|
| PACKING GROUP |
|
| HAZARD SYMBOL |
XI |
|
RISK PHRASES |
36/37/38 |
|
SAFETY PHRASES |
26 |
|
|
| EXTERNAL LINKS & GENERAL INFORMATION | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Wikipedia Linking: http://en.wikipedia.org/wiki/Calcipotriene The pharmacology action of Calcipotriene is that Calcipotriene is a synthetic vitamin D 3 analog. In a manner similar to vitamin D, calcipotriene regulates skin cell production and development, thereby modifying the abnormal growth and production of keratinocytes, responsible for the scaly red patches characteristic of psoriasis. (http://www.health-care-clinic.com/) Calcipotriene (brand name Dovonex) is a form of synthetic Vitamin D3. It is not the same as the Vitamin D found in dietary supplements taken by mouth, which should not be used to treat psoriasis. Calcipotriene is formulated to slow skin cell growth, flatten lesions and remove scale. It can also be used to treat psoriasis of the scalp and nails. (http://www.psoriasis.org/) Calcipotriene, used to treat psoriasis in humans, is available as an ointment or cream (0.005% or 50 µg/g). Calcipotriene is a novel structural analog of calcitriol (1,25-dihydroxycholecalciferol), the most active metabolite of cholecalciferol (vitamin D3). Accidental ingestion of 40-60 µg/kg of calcipotriene in dogs has been associated with life-threatening hypercalcemia. Clinical signs usually occur within 24-72 hr of ingestion and include anorexia, vomiting, diarrhea, polyuria, polydipsia, depression, and weakness. Serum calcium is usually elevated within 12-24 hr and may remain above normal for weeks. This is usually accompanied by an increase in serum phosphorous concentration and calcium phosphorous product (Ca × P) and soft tissue mineralization. Acute renal failure as evidenced by elevated BUN and creatinine levels, coma, and death occur in severe or untreated cases. (http://www.merckvetmanual.com/)
|
|
|
| SALES SPECIFICATION |
|
|
APPEARANCE |
white to off-white crystalline powder |
| IDENTIFICATION |
pass test (IR) |
|
ASSAY |
95.5 - 102.0% min (HPLC) |
| MELTING POINT | 225 - 232 C |
|
RELATED SUBSTANCES |
Individual
impurity: 1.0% max |
| LOSS ON DRYING |
1.0%
max
|
| HEAVY METALS |
20ppm max |
| RESIDUAL SOLVENTS |
Tetrahydrofuran: 750ppm Ethyl acetate: 5000ppm Petroleum ether: 1000ppm Methanol: 3000ppm Toluene: 900ppm |
|
|
| PACKING |
|
|
|
|
| PRICE INFORMATION |