CALCITONIN

Synonyms. Calcitonin (salmon); Thyrocalcitonin); Tonocalcin; Thyrocalcitonin; Calcimar ; Calcitonin salmon; Cibacalcin; 鲑降钙素;鲑鱼降钙素; Fortical; Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys- Leu-Ser-Gln- Glu-Leu-His-Lys-Leu- Gln-Thr-Tyr-Pro-Arg-Thr-Asn- Thr-Gly-Ser-Gly-Thr-Pro-NH2 [Disulfide bridge: 1-7];

CALCITONIN

 

PRODUCT IDENTIFICATION

CAS RN

47931-85-1, 9007-12-9

EINECS RN

256-342-8, 232-693-2 

FORMULA

C145H240N44O48S2

MOLE WEIGHT

3431.85

H.S CODE

 2937.19.0000

SMILES

 C1N(C([C@@H](NC(CNC([C@@H](NC(CNC([C@@H](NC ([C@@H] (NC([ C@ @H](NC([C@@H](NC([C@@H]2N(CCC2)C([ C@@H](NC([C@@H](NC (=O)[C@@H](CCC(N)=O)NC(=O) [C@@H](CC(C)C)NC([C@@H]( NC([C@ @H] (NC([C@@H] (NC([C@@H](NC([C@@H](CCC(N)=O)NC([C@@H](NC ([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@ H]2NC (=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](CO)NC(=O)[C@@H](NC ([C@@H](NC(=O)[C@@H](CO)NC(=O)[C@@H](N)CSSC2)CC(N)=O)=O)CC (C)C)=O)C(C)C) =O)CC(C)C)=O)=O)CCCCN)=O)CC(C)C)=O)CO)= O)=O) CC C(= O)O)=O)CC(C)C)=O)Cc2cnc[nH]2)=O)CCCCN)=O)[C@@H](O)C )=O)Cc2 ccc(cc2)O)=O)=O)CCCNC(N)=N)=O)[C@@H](O)C)=O)CC(N) =O) =O)[C@ @H](O)C)=O)=O)CO) =O)=O)[C@@H](O)C)=O)[C@@H](CC1) C(=O)N

CLASSIFICATION

Bone density conservation agent, Linear Polypeptide

EXTRA NOTES

 32 amino acid polypeptide, 8 of which are conserved across all species.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong acids, Strong bases

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2,Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking: http://en.wikipedia.org/wiki/Calcitonin

Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. In birds, fish and amphibians, calcitonin is secreted from the ultimobrachial glands. Calcitonin is a 32 amino acid peptide cleaved from a larger prohormone. It contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding CGRP; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family. (http://arbl.cvmbs.colostate.edu/)

Calcitonin is used to lower high blood calcium levels in people who have cancer that is in the bones. It is also used to treat other conditions, including osteoporosis in women past menopause and Paget's disease of the bone. Multiple myeloma and some cancers that spread to the bones can break down bone materials and release large amounts of calcium into the blood. This condition, known as hypercalcemia, can be dangerous. Calcitonin is a hormone normally made by the thyroid gland. It helps keep calcium levels in the body from getting too high. It does this mainly by blocking the breakdown (absorption) of bone, which slows the release of more calcium into the blood. It also helps the kidneys rid the body of the excess calcium in the blood. It affects the intestines as well, lowering the amount of calcium entering the body through food. As a drug, calcitonin-salmon is a man-made version of the hormone as it is found in salmon (which is more potent and lasts longer than the human form). Taking the drug raises calcitonin levels in the body, which leads to lower blood calcium levels within a few hours. http://www.cancer.org/)

Calcitonin is a naturally occurring hormone. It helps regulate calcium levels in your body and is involved in the process of bone building. When taken by shot or nasal spray, it slows the rate of bone thinning. It also relieves pain that occurs when the bones in the spine (vertebrae) break and collapse on top of each other (spinal compression fracture). Calcitonin is used in women with osteoporosis to reduce bone loss. It reduces spinal bone (vertebrae) fractures when taken by postmenopausal women for at least 1 year. It may be prescribed for women who are more than 5 years beyond menopause and who do not tolerate bisphosphonate medications. Calcitonin can be used in men with osteoporosis who have normal levels of the male sex hormone testosterone or whose osteoporosis does not get better with testosteron treatment. Calcitonin relieves pain caused by spinal compression fractures. (http://www.svcmc.org/)

 

Calcitonins

 

Product

CAS RN

Calcitonin

9007-12-9
Calcitonin (porcine) 12321-44-7
Calcitonin (human) 21215-62-3
Calcitonin 47931-85-1
Calcitonin (human) trihydrochloride 56612-22-7
Procalcitonin 56645-65-9
Calcitonin (eel) 57014-02-5
Elcatonin 60731-46-6
2-Deserinecalcitonin (salmon) 75660-90-1
Preprocalcitonin 80296-97-5
37-Amino acid peptide-CGRP 83652-28-2
Katacalcin 85916-47-8
16-Deleucinecalcitonin (salmon) 86370-00-5
16-Dephenylalanine calcitonin (human) 86370-01-6
8-Glycinecalcitonin (salmon) 88433-78-7
8-Valinecalcitonin (human) 89355-26-0
ProCGRP 95077-07-9
8-Glycinecalcitonin (human) 95548-37-1
Avicatonin 103451-84-9
2,7-Asu-CGRP 108568-91-8
(Arg-3-nitrophenylazido-lys)calcitonin 114451-34-2
8-Gly-16-ala-19-de-leu-calcitonin (salmon) 114869-79-3
Gly(8)-des-leu(16)-arg(24)-calcitonin (salmon) 115888-20-5
Arg(11,18)-lys(14)-calcitonin (salmon) 116381-07-8
(4-Azidobenzoyl)-arg(11,18)-lys(14)-calcitonin 116469-30-8
8-Val-37-phe-CGRP 119911-68-1
N(alpha)-Propionyl-1,7-di-ala-19-des-leu-salmon calcitonin 120318-94-7
Fortical 135506-95-5
tert-Butyl-cys(18)-CGRP (19-37) 137908-73-7
Boc-cyclo(cys-ser(tbu)-asn-leu-ser(tbu)-thr(tbu)-cys)-val-leu-gly-OH 139555-60-5
N-Acetyl-30-L-asparagine-32-L-tyrosinamide-8-32-calcitonin (salmon ) 161902-50-7
Davalintide 863919-85-1
Davalintide acetate 879197-42-9

 

SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

Pass Test I, II (TLC, HPLC)

AMINO AID ANALYSIS

 Asp: 1.8 - 2.2
Glu: 2.7 - 3.3
Pro: 1.7 - 2.3
Gly: 2.7 - 3.3
Val: 0.9 - 1.1
Leu: 4.5 - 5.3
His: 0.9 - 1.1
Arg: 0.9 - 1.1
Lys: 1.8 - 2.2
Ser: 3.2 - 4.2
Thr: 4.2 - 5.2
Tyr: 0.7 - 1.1
Half-cystine: 1.4 - 2.1

PEPTIDE CONTENT

 97.5% min

ASSAY

 90.0 - 105.0%

WATER

10.0% max

pH

4.9 - 5.7 (1% aq. solution)
HEAVY METALS 20ppm max

SULFATES

300ppm max

CHLORIDE

200ppm max

ACETATE CONTENT

15.0% max

RELATED SUBSTANCES

Individual impurity: 1.0% max
Total impuriry: 2.0% max 

MICROBIOLOGY

Total viable aerobic count: 100CFU/g max
Bacterial endotoxins: 25IU/mg max
RESIDUAL SOLVENTS Ethanol 0.2% max
Acetonitrile: 0.04% max
Methylene chloride: 600ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not known

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Harmful if swallowed. Target Organ Effect, Toxic by ingestion. Target Organs:Bone, Kidney

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H301

P STATEMENTS

P301 + P310

EC DIRECTIVES

 

HAZARD CODES

 

RISK PHRASES

 22-36-51/53

SAFETY PHRASES

 26-61

 

PACKING