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CORTICOTROPIN |
| Synonyms. Corticotropin; ACTH; Acethropan; Acortan; Acorto; Acthar; Acton; Actonar; Adrenal cortex hormone; Adrenocorticotrophic hormone; Adrenocorticotrophin; Adrenocorticotropin; Adrenomone; Adrenotrophin; Alfatrofin; Cibacthen; Corstiline; Corticotrofina; Corticotrophin; Corticotrophinum; Corticotropin; Corticotropina; Corticotropine; Corticotropinum; Cortiphyson; Cortrophin; Dynamone; Isactid; Reacthin; Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His- Leu- Leu- Arg-Glu- Val-Leu-Glu-Met-Ala-Arg-Ala-Glu- Gln- Leu-Ala-Gln-Gln-Ala-His-Ser-Asn -Arg-Lys- Leu-Met- Glu -Ile-Ile-NH2 |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
9002-60-2, 55127-96-3 |
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EINECS RN |
232-659-7 |
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FORMULA |
C208H344N60O63S2 |
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MOLE WEIGHT |
4757.45 |
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H.S CODE |
2933.29.3500 |
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SMILES |
CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O )NC (=O)C2CCCN2C(=O)C (CC3=CC=CC=C3)NC(=O)C(C)NC(=O)C (CCC (=O)O )NC(=O)C(C)NC(=O)C(CO)NC(=O)C (CCC(=O)O)NC(=O)C(CC (=O)O )NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(= O)N)NC (=O)C4CCCN4C(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C (CCCCN)NC(= O)C(C(C)C)NC(=O)C6CCCN6C (=O)C(CCC NC(=N)N) NC(=O)C(CCCN C(=N) N)NC(=O)C (CCCCN)NC(=O)C(CCCCN) NC(=O) CNC( =O)C(C(C)C) NC(=O)C7CCCN7C(=O)C(CCCCN)NC(= O)CNC (=O)C(CC8=CN C9=CC =CC =C98)NC(=O)C(CCCNC(=N)N)NC (=O)C(CC 1=CC=CC=C1)NC (=O)C (CC1=CN=CN1)NC(=O)C(CCC(=O) O)NC(=O) C(CCSC)NC(=O)C(CO) NC(=O)C (CC1= CC=C(C=C1)O) NC(=O)C(CO)N |
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CLASSIFICATION |
Hormone (adrenocorticotropic); Glucocorticoid; Diagnostic aid (adrenocortical insufficiency), Linear Polypeptide |
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EXTRA NOTES |
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress. |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white powder |
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MELTING POINT |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY | |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pH |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong acids, Strong bases |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2,Flammability:0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikipedia Linking: http://en.wikipedia.org/wiki/Corticotropin Adrenocorticotropic hormone, as its name implies, stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. ACTH is secreted from the anterior pituitary in response to corticotropin-releasing hormone from the hypothalamus. corticotropin-releasing hormone is secreted in response to many types of stress, which makes sense in view of the "stress management" functions of glucocorticoids. Corticotropin-releasing hormone itself is inhibited by glucocorticoids, making it part of a classical negative feedback loop. (http://www.vivo.colostate.edu/) A 39 amino acid polypeptide, corticotropin is secreted from the anterior pituitary. The first 24 amino acids (from the N-terminal end of the chain) define its biologic activity. While human, sheep, cattle and swine corticotropin have different structures, the first 24 amino acids are the same and, therefore, biologic activity is thought to be identical. Commercial sources of ACTH generally are obtained from porcine pituitaries. One USP unit of corticotropin is equivalent to 1 mg of the international standard. (http://www.elephantcare.org/)An anterior pituitary hormone that stimulates the adrenal cortex to secrete its hormones, including corticosterone. If production of corticotropin falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines. Called also adrenocorticotrophic hormone. A pharmaceutical preparation of animal-derived corticotropin, administered intravenously for diagnostic testing of adrenocortical function and subcutaneously or intramuscularly as an anticonvulsant for treating infantile spasms. Called also adrenocorticotrophic hormone, adrenocorticotropin, and corticotrophin. (http://www.mercksource.com/)
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| SALES SPECIFICATION |
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APPEARANCE |
white to off-white powder |
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IDENTIFICATION |
Pass Test (HPLC) |
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AMINO AID ANALYSIS |
Asp: 1.8 - 2.2 + Glu: 4.5 - 5.5 + Pro: 3.6 - 4.4 + Gly: 2.7 - 3.3 + Val: 2.7 - 3.3 + Leu: 1.8 - 2.2 + His: 0.9 - 1.1 + Arg: 2.7 - 3.3 + Lys: 3.6 - 4.4 + Ser: 1.8 - 2.2 + Met: 0.9 - 1.1 + Tyr: 1.8 - 2.2 + Phe: 2.7 - 3.3 + Ala: 2.7 - 3.3 + Trp: 0.9 - 1.1 |
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PEPTIDE CONTENT |
95.0% min |
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ASSAY |
70 IU/mg min |
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WATER |
7.0% max |
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ACETIC ACID |
15.0% min (Trifluroracetic acid: 0.5% max) |
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MICROBIOLOGY |
Total
viable aerobic count: 100CFU/g max |
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RESIDUAL SOLVENTS |
DMF: 0.1% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
Not known |
| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION |
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HAZARD OVERVIEW |
Harmful if swallowed. |
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GHS |
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SIGNAL WORD |
Warning |
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RISK PHRASES |
22-36-51/53 |
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SAFETY PHRASES |
26-61 |
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| PACKING |
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