MANGIFERIN
2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one; Alpizarin; Alpizarine; Aphloiol; Chinomin; Chinonin; 1,3,6,7-Tetrahydroxy-2-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2- yl)xanthen-9-one; ,3,6,7-Tetrahydroxyxanthone C2-beta-D-glucoside;

MANGIFERIN
 

PRODUCT IDENTIFICATION

CAS RN

 4773-96-0, 99331-60-9

EINECS RN

  

FORMULA

 C19H18O11

MOLE WEIGHT

 422.34

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

yellow crystalline powder

MELTING POINT

 274 C

BOILING POINT

  

DENSITY

  

SOLUBILITY IN WATER

 

pH

 

VAPOR DENSITY

 

REFRACTIVE INDEX

  

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

 Strong oxidizing agents
DECOMPOSITION PRODUCTS

Carbon oxides
POLYMERIZATION Has not been reported

NFPA RATINGS

Health: 4; Flammability: 0; Reactivity:0

 

SAFETY

HAZARD NOTES

 Highly Toxic. Very toxic if swallowed. Target organs: Immune system.

EYE

  

SKIN

  

INGESTION

 

INHALATION

  

CHRONIC

  

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 3462
HAZARD CLASS

6.1
PACKING GROUP

I

HAZARD SYMBOL

T+

RISK PHRASES

 28

SAFETY PHRASES

22-28-36/37-45

 

OTHER INFORMATION
Xanthene is a polyaromatic cyclic ether compound which have one oxygen in the ring system.  Two benzene rings are fused to tetrahydropyran which is a six membered cyclic ether with  five carbons and one oxygen. It is soluble alcohol and ether. Pyran ring structure is the basis of the pyranoses. Xanthene is used as a fungicide itself. But the main function is as the fundamental structure of chromophore particularly luminescent dyes.  Xanthene class dyes include fluorenes, pyronins, succineins, sacchareins, rosamines, rhodamines, rhodols and fluorones.  Xanthone is the xanthene ketone. It is used as an ovicide and as a larvicide. The structure of xanthone is found in natural constituents of plants (specially in mangosteen fruits) and micro-organisms. Naturally occurring xanthones are under research in activating biological properties for antioxidant and various pharmaceutical activities including anti-inflammatory, anticancer, and central nervous system depressants. Synthetic xanthone can be prepared from phenyl salicylate. Synthetic hydroxyxanthones are used as a plastic additive for the resistance to degradation by light and UV. (Xanthine is not a xanthene structure compound but dioxopurine, a precursor of uric acid). Some example of hydroxyxanthone are:

Product

CAS RN.

Gentisein

529-49-7
Euxanthone 529-61-3
1-Hydroxyxanthone 719-41-5
2-Hydroxyxanthone 1915-98-6
Demethylbellidifolin 2980-32-7
1,3-Dihydroxyxanthone 3875-68-1
Mangiferin 4773-96-0
Mesuaxanthone B 5042-03-5
2,3,4-Trihydroxyxanthone 6563-41-3
Norswertianin 22172-15-2
2,5-Dihydroxyxanthone 35040-32-5
3,4-Dihydroxyxanthone 39731-48-1
Norswertianolin 54954-12-0
Wubangziside C 99759-20-3
Mangiferin, 2-.BETA.-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, obtained directly from methanolic extracts of Bombax ceiba leaves in substantial amounts demonstrated strong antioxidant activity (EC50 5.8.+-.0.96.MU.g/ml or 13.74.MU.M) using DPPH assay comparable to rutin, commonly used as antioxidant for medical purposes. The acetyl and cinnamoyl derivatives were found to be less active than mangiferin whereas, methyl and 3,6,7-trimethylether tetraacetate derivatives were inactive implying that for antioxidant activity, free hydroxyl groups and catechol moiety are essential. Moreover, mangiferin showed hepatoprotective activity against carbon tetrachloride induced liver injury further supporting the free radical scavenging property in the in vivo system. Additionally, plant extracts and mangiferin failed to exhibit acute anti-inflammatory activity whereas, it displayed significant analgesic effect in acetic acid-induced writhing and hot plate tests in mice. Using naloxone, it was revealed that plant extracts induced analgesia was independent of opioid receptor, whereas, mangiferin demonstrated significant interaction with it at peripheral site with a slight contribution at the neuronal level. (author abst.) http://sciencelinks.jp/

 

SALES SPECIFICATION

APPEARANCE

 yellow crystalline powder

ASSAY

95.0% max

HEAVY METALS

 20ppm max

 

PACKING

 

 

PRICE INFORMATION