O-DESMETHYLMETOPROLOL
4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneethanol; 1-(4-(2-Hydroxyethyl)phenoxy)-3- (propan-2-ylamino)propan-2-ol; 4-(2-Hydroxy-3-(isopropylamino)propoxy)phenylethyl Alcohol;

O-DESMETHYLMETOPROLOL
 

PRODUCT IDENTIFICATION

CAS RN

 62572-94-5

EINECS RN

  

FORMULA

 C14H23NO3

MOLE WEIGHT

 253.34

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

 off-white powder

MELTING POINT

  

BOILING POINT

  

DENSITY

 

SOLUBILITY IN WATER

 

pH

 

VAPOR DENSITY

 

REFRACTIVE INDEX

  

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions

INCOMPATIBLE MATERIALS

Strong oxidizing agents, Water
DECOMPOSITION PRODUCTS

Carbon oxides, silicon oxides
POLYMERIZATION

Will not occur.

NFPA RATINGS

Health: 2. Flammability: 1, Reactivity: 0

 

SAFETY

HAZARD NOTES

Combustible Liquid, Irritant

EYE

Causes eye irritation.

SKIN

May be harmful if absorbed through skin. Causes skin irritation.

INGESTION

May be harmful if swallowed.

INHALATION

May be harmful if inhaled. Causes respiratory tract irritation.

CHRONIC

 

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

  
HAZARD CLASS

 
PACKING GROUP

 

HAZARD SYMBOL

XI

RISK PHRASES

38

SAFETY PHRASES

26-36

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking : http://en.wikipedia.org/wiki/Metoprolol

Metoprolol, first introduced in 1975, is one of a class of drugs known as beta-blockers. Beta-blockers are widely prescribed to treat disorders of the heart and circulation. They work by blocking the action of adrenaline (epinephrine) and noradrenaline (norepinephrine) - two chemicals produced by the body that increase heart rate and raise blood pressure. Cardioselective beta-blockers are especially effective at slowing heart rate and reducing the force of the heartbeat, thereby reducing the workload of the heart. These actions make beta-blockers, including metoprolol, particularly effective in the treatment of a range of cardiovascular problems. Metoprolol can be prescribed for: high blood pressure, angina (the condition caused by narrowing of the arteries and reduction in the amount of oxygen-carrying blood reaching the heart), patients who have had a heart attack, heart failure (a condition arising from weakening of the heart muscle which makes the heart pump less efficiently), certain disturbances of cardiac rhythm (arrhythmias), disorders of the function of the heart involving palpitations. (http://www.ctsu.ox.ac.uk/)

Metoprolol: a cardioselective beta1-adrenoreceptor blocking agent in the treatment of hypertension, angina pectoris, and myocardial infarction. Metoprolol tartrate, tartrate salt of metoprolol, is a white crystalline powder, practically odorless; soluble in water; soluble in methylene chloride, chloroform, and alcohol, insoluble in ether; chemically (±)-1-(isopropylamino)-3-(p-(2-(methoxyethyl) phenoxy)-2-propanol (2:1) dextro-tartrate salt; administered orally and intravenously. Examples of alpha-beta combined brokers are carvedilol and labetalol, alpha-Brokers; alfuzosin, doxazosin, indoramin, phenoxybenzamine, phentolamine, prazosin, tamsulosin, terazosin, thymoxamine and beta-blockers examples include atenolol, metoprolol, oxprenolol, propranolol (most of the generic names for beta blockers end with 'olol').

O-Demethylmetoprolol is a pharmacologically active urinary metoprolol metabolite 5 to 10X less potent than metoprolol. 

 

SALES SPECIFICATION

APPEARANCE

 Clear liquid

PURITY

98.0% min (GC)

 

PRICE