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SELENIOUS ACID |
| Hydrogen Selenite; Monohydrated selenium dioxide; Selenite; Selenium dioxide; Selenous acid; Selenium dioxide monohydrate; |
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| PRODUCT IDENTIFICATION |
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CAS RN |
7783-00-8; 11140-60-6 |
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EINECS RN |
231-974-7 |
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FORMULA |
H2SeO3 |
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MOLE WEIGHT |
128.97 |
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| PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE |
white to almost white powder |
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MELTING POINT |
70 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
Readily soluble (very soluble in hot water and alcohol insoluble in ammonia) |
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pH |
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VAPOR DENSITY |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions |
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INCOMPATIBLE MATERIALS |
Strong reducing agents, fine metal powder |
| DECOMPOSITION PRODUCTS | selenium, selenium oxides |
| POLYMERIZATION | Has not been reported |
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NFPA RATINGS |
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| SAFETY |
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HAZARD NOTES |
Toxic by inhalation and if swallowed. Danger of cumulative effects. Very toxic to aquatic organisms, may cause long-term adverse effects, in the aquatic environment. Hygroscopic. |
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EYE |
May cause severe eye irritation. May result in corneal injury. |
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SKIN |
May cause severe skin irritation. May be absorbed through the skin in harmful amounts. Prolonged or repeated contact may cause irritation or dermatitis. |
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INGESTION |
May be fatal if swallowed. May cause liver and kidney damage. May cause burns to the digestive tract. |
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INHALATION |
May be fatal if inhaled. May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. |
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CHRONIC |
Symptoms demonstrated by humans suffering from chronic selenium intoxication, selenosis, include depression, languor, nervousness, dermatitis, gastrointestinal disturbances, giddiness, garlic odor of the breath and sweat, moderate emotional instability, excess dental caries, and in extreme cases, loss of fingernails and partial alopecia. |
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| TRANSPORT & REGULATORY INFORMATION |
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UN NO. |
6.1 |
| HAZARD CLASS | 3283 |
| PACKING GROUP |
II |
| HAZARD SYMBOL |
T, N |
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RISK PHRASES |
23/25-33-50/53 |
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SAFETY PHRASES |
20/21-28-45-60-61 |
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| OTHER INFORMATION |
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1.Colorless solid, transparent, colorless crystals. Used as a reagent for
alkaloids and as an oxidizing agent. Isotope is used in labeling
radiopharmaceuticals. (EPA, 1998)
SELENIOUS ACID decomposes when heated to toxic and volatile selenium dioxide. Serves as an oxidizing agent. Reacts exothermically with many reducing agents including hydroiodic acid, sulfurous acid, sodium hyposulfite, hydroxylamine salts, hydrazine salts, hypophosphorous acid, phosphorous acid [Merck]. Oxidizes many organic substances. Is oxidized to selenic acid by strong oxidizing agents. (NOAA REACTIVITY, 2007) (source: http://cameochemicals.noaa.gov/chemical/5172) 2.Selenium (Se) can protect endothelial cells (EC) from oxidative damage by altering the expression of selenoproteins with antioxidant function such as cytoplasmic glutathione peroxidase (cyGPX), phospholipid hydroperoxide glutathione peroxidase (PHGPX) and thioredoxin reductase (TR). If the role of Se on EC function is to be studied, it is essential that a model system be chosen which reflects selenoprotein expression in human EC derived from vessels prone to developing atheroma. We have used [75Se]-selenite labelling and selenoenzyme measurements to compare the selenoproteins expressed by cultures of EC isolated from different human vasculature with EC bovine and porcine aorta. Only small differences were observed in selenoprotein expression and activity in EC originating from human coronary artery, human umbilical vein (HUVEC), human umbilical artery and the human EC line EAhy926. The selenoprotein profile in HUVEC was consistent over eight passages and HUVEC isolated from four cords also showed little variability. In contrast, EC isolated from pig and bovine aorta showed marked differences in selenoprotein expression when compared to human cells. This study firmly establishes the suitability and consistency of using HUVEC (and possibly the human cell line EAhy926) as a model to study the effects of Se on EC function in relation to atheroma development in the coronary artery. Bovine or porcine EC appear to be an inappropriate model.(source: http://lib.bioinfo.pl/meid:43993) |
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| SALES SPECIFICATION |
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APPEARANCE |
white to almost white crystalline powder |
| ASSAY |
98.0% min |
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Se CONTENT |
60.4% min |