THYMOPENTIN

Synonyms. Thymopentin; N-(N-(N-(N2-L-Arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)-L-tyrosine; Thymopentine; Thymopentinum; Timopentina; Thymopoietin pentapeptide; Arg-Lys-Asp-Val-Tyr; Sintomodulina; Mepentil; Timunox; TP-5; (3S)-3-(((2S)-6-amino-2-(((2S)-2-amino-5- (diaminomethy lideneamino) pentanoyl) amino) hexanoyl) amino)-4-(((2S)-1-(((2S)-1-hydroxy-3-(4-hydroxyphenyl)-1- oxopropan-2-yl)amino)-3-methyl-1- oxobutan- 2-yl)amino)-4-oxobutanoic acid; Arg-Lys-Asp-Val-Tyr; Thymopoietin pentapeptide;

THYMOPENTIN

 

PRODUCT IDENTIFICATION

CAS RN

69558-55-0, 177966-81-3 (acetate)

EINECS RN

FORMULA

C30H49N9O9

MOLE WEIGHT

679.76

H.S CODE

 2933.99.4600

SMILES

 C([C@@H](NC([C@@H](NC([C@@H](CCCNC(N)=N)N)=O) CCCCN)= O)CC(O)=O)(N[C@@H](C(N[C@@H](Cc1ccc(O)cc1)C(O) =O)=O)C(C) C)=O

CLASSIFICATION

Polypeptide, Immunologic adjuvant, Immunomodulator

EXTRA NOTES

 A synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Soluble (soluble in 1% acetic acid)

SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong acids, Strong bases

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2,Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Thymopentin, also known as TP-5, is a synthesized derivative of thymopoietin, a naturally occurring hormone responsible for inducing T-cell precursors to differentiate and mature. A study at the Istituto di Patologia Medica in Bari, Italy, reported thymopentin-related increases in T4 cells and some improvement in symptoms for 21 people. Two studies of thymopentin published at the Sixth International Conference on AIDS pointed to stabilization of T-helper counts and p24 antigenemia in asymptomatic and mildly symptomatic patients during treatment with thymopentin. One of the studies was too small to see differences in disease progression. In the larger study, none of the treated patients progressed to symptoms, compared to four of the placebo patients who did progress. No side effects were attributed to thymopentin (http://www.aids.org/)

A synthetic pentapeptide which is the active site of the naturally occurring hormone thymopoietin with immunomodulating properties. Thymopentin enhances the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects. This agent also augments the effects of ionizing radiation by arresting cancer cells in the G2/M phase of the cell cycle.(http://www.cancer.gov/)

Thymopentin is a synthetic pentapeptide. It can modulate immune system. Laboratories research and clinical results both show that it normalizes the immune function in two directions (promoting or inhibiting) in various cases of derangement, whether in suppression or hypersensitivity. Thus it is emerging as an immune regulatory agent with great potential. Besides its activity in the immune system, it was discovered to reduce the content of propane dialdehyde in brain, thymus and liver, enhance the activity of SOD at the same moment of improving its content, thus eliminate the radicals in human body and reduce the level of lipid peroxides. All the above illuminate that it has affects against aging and some circulatory system diseases. (http://thymosin.net/)

 

SALES SPECIFICATION

APPEARANCE

 white to slightly yellowish powder
IDENTIFICATION

pass (HPLC)

PURITY

98.0% min
AMINO ACID 1.0 ± 10% (each theoretical Composition)

RELATED SUBSTANCES

2.0% max (total impurity), 1.0% max (Individual impurity)
PEPTIDE CONTENT
80.0% min (N determination)
pH 7.0 ~ 9.0
WATER CONTENT 8.0% max
OPTICAL ROTATION -14.0° ~ -22.0°
BACTERIAL ENDOTOXINS 5EU/mg max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not known

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Avoid contact and inhalation. May causes eye irritation. May causes skin irritation. May cause gastrointestinal irritation. May causes respiratory tract irritation
HAZARD CODES

 

RISK PHRASES

  

SAFETY PHRASES

22-24/25

 

PACKING