SCHIZANDRIN

Synonyms. Gomisins; Magnolia Vine; Wuweizichun A; Wuweizi alcohol A; (+)-Schizandrin; Schisandrin; Schisandrine; Schisandrol A; Schizandrine; 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2,3,10,11,12-hexamethoxydibenzo(a,c) cycloocten-6-ol, stereoisomer;

SCHIZANDRIN

 

PRODUCT IDENTIFICATION

CAS RN

7432-28-2

EINECS RN

 

FORMULA

C24H32O7

MOLE WEIGHT

432.51

H.S CODE

2909.49.1000

SMILES

c12c3c(cc(OC)c(c3OC)OC)C[C@@H](C)[C@@](Cc1cc(OC)c(c2OC) OC)(C)O

CLASSIFICATION

Schizandra

EXTRA NOTES

A dibenzocyclooctadiene lignan present in the fruit of Schisandra chinensis

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 
SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

3.526

VAPOR PRESSURE

 

AUTOIGNITION TEMP

 
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong Oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health hazard: 1, Flammability: 0, Physical hazards: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Schizandrin

PubChem Compound Summary - Schizandrin

Drug Bank -  Schizandrin

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Schizandrin

http://www.ebi.ac.uk/ -  Schizandrin

http://www.ncbi.nlm.nih.gov/ - Schizandrin

http://www.sciencedirect.com/
The total synthesis of gomisin A and
schizandrin having natural configurations were accomplished for the first time. The key feature of these syntheses is a highly efficient intramolecular oxidative coupling of the intermediates and, which can be obtained as both enantiomers in optically pure forms. The manipulation of the lactone moieties of and afforded natural enantiomers of schizandrin and gomisin A

http://www.sigmaaldrich.com/
Biochem/physiol Actions: Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

 

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

98.0% min

OPTICAL ROTATION

75° ~ 85°

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

3077

HAZARD SYMBOL

Class: 9

PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards:Harmful by ingestion

GHS

 

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H320-H400

P STATEMENTS

P273

EC DIRECTIVES

 

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 

 

PACKING

 

 

PRICE INFORMATION