SCHIZANDRIN
Synonyms. Gomisins; Magnolia Vine; Wuweizichun A; Wuweizi alcohol A; (+)-Schizandrin; Schisandrin; Schisandrine; Schisandrol A; Schizandrine; 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2,3,10,11,12-hexamethoxydibenzo(a,c) cycloocten-6-ol, stereoisomer;

SCHIZANDRIN
 

PRODUCT IDENTIFICATION

CAS RN

 7432-28-2

EINECS RN

  

FORMULA

 C24H32O7

MOLE WEIGHT

 432.51

H.S CODE

 2909.49.1000

SMILES

 c12c3c(cc(OC)c(c3OC)OC)C[C@@H](C)[C@@](Cc1cc(OC)c(c2OC) OC)(C)O

CLASSIFICATION

 Schizandra

EXTRA NOTES

 A dibenzocyclooctadiene lignan present in the fruit of Schisandra chinensis

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white powder

MELTING POINT

  

BOILING POINT

  

DENSITY

 

SOLUBILITY IN WATER

  
SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

3.526

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong Oxidizing agents
POLYMERIZATION

Has not been reported

NFPA RATINGS

Health hazard: 1, Flammability: 0, Physical hazards: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Schizandrin

PubChem Compound Summary - Schizandrin

Drug Bank -  Schizandrin

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Schizandrin

http://www.ebi.ac.uk/ -  Schizandrin

http://www.ncbi.nlm.nih.gov/ - Schizandrin

http://www.sciencedirect.com/
The total synthesis of gomisin A and schizandrin having natural configurations were accomplished for the first time. The key feature of these syntheses is a highly efficient intramolecular oxidative coupling of the intermediates and, which can be obtained as both enantiomers in optically pure forms. The manipulation of the lactone moieties of and afforded natural enantiomers of schizandrin and gomisin A

http://www.sigmaaldrich.com/
Biochem/physiol Actions: Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

 

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

98.0% min
OPTICAL ROTATION

75° ~ 85°

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

3077

HAZARD SYMBOL

Class: 9
PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards:Harmful by ingestion

GHS

  

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H320-H400

P STATEMENTS

P273
EC DIRECTIVES

 
HAZARD CODES

 

RISK PHRASES

  

SAFETY PHRASES

  

 

PACKING

 

 

PRICE INFORMATION