THIOFLAVIN T

THIOFLAVIN T
PRODUCT IDENTIFICATION
CAS NO.	2390-54-7
EINECS NO.	219-228-9
FORMULA	C₁₇H₁₉ClN₂S
MOL WT.	318.86
H.S. CODE
TOXICITY
CLASSIFICATION	Coloring Agent, Indicator, Luminescent Agent, Categories: Benzothiazole, Quaternary ammonium compound
SYNONYMS	Basic Yellow T; Basic yellow 1;
3,6-Dimethyl-2-dimethylaminophenylbenzothiazolium chloride; C.I. 49005; C.I. Basic Yellow 1; Citroflavine 8G; Methyldehydrothio-p-toluidine sulfonate; Methylene Yellow N; Methylene Yellow NI; Nankai Basic Flavine 8G; Primoflavine 8G; Purimofurabin 8G; Rhoduline Yellow; Setoflavin T; Setoflavine T; Tannoflavine T; Thioflavin TCN; Thioflavin TG; Thioflavine T; Thioflavine TCN; Thioflavine TCND; 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride; 2-(p-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride; Brilliant Flavine T;
SMILES	c1(c2ccc(N(C)C)cc2)sc2cc(C)ccc2[n+]1C.[ClH-]
EXTRA NOTES	Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	yellowish powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	soluble
SOLUBILITY
AUTOIGNITION
pH
VAPOR DENSITY
NFPA RATINGS	Health: 2; Flammability: 1; Reactivity: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions
EXTERNAL LINKS & GENERAL DESCRIPTION
USA.gov - Thioflavine T Wikipedia Linking - Thioflavin Google Scholar Search - Thioflavine T Drug Information Portal (U.S. National Library of Medicine) - Thioflavin T PubChem Compound Summary - Thioflavine T http://www.ncbi.nlm.nih.gov/ - Thioflavine T EPA - Substance Registry Services - Thioflavine T Local: The IUPAC Name of free base primuline (mole formula: C₂₁H₁₄N₃NaO₃S₃ mole wt.: 475.53893 g/mol) is 2-[2-(4-Aminophenyl)-1,3-benzothiazol-6-yl]-6-methyl-1,3-benzothiazole-7-sulfonic acid which has the featured methylated and sulfonated benzothiazole ring, derived from dehydrothiotoluidine. Commercially available primuline is usually the homogenous mixture of sodium salts, which should have at least three benzothiazole rings. Primuline (Direct Yellow 59), also called thioflavin S , is a fluorescent dye which used to mark or label other compounds with fluorescent tags. The wave length of the emitted light from fluorescent dye is usually longer than that of the incident light. Thioflavin S is the result from the methylation of dehydrothiotoluidine in the presence of sulfuric acid. Thioflavine T (Basic Yellow 1) is 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline which is derived from dehydrothiotoluidine by the methylation with hydrochloric acid. They bind to amyloid fibrils and gives a distinct spectral shift; used to diagnose amyloid fibrils, both ex vivo and in vitro.
SALES SPECIFICATION
APPEARANCE	yellowish powder
DYE CONTENT	75.0%
ABSORPTION	411 - 414nm
LOSS ON DRYING	15.0% min
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
HAZARD OVERVIEW	Not a dangerous substance according to GHS (Globally Harmonised System). Eyes: May cause eye irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Ingestion: May be harmful if swallowed.
HAZARD CODES
RISK PHRASES
SAFETY PHRASES