TROPINONE
|
3-Tropanone; Tropanon; Tropanone; 1alphaH,5alphaH-Tropan-3-one; 8-Methyl-8-azabicyclo(3.2.1)
octan-3-one; |
|
PRODUCT
IDENTIFICATION
|
CAS
RN
|
532-24-1
|
EINECS
RN |
208-530-6 |
FORMULA |
C8H13NO |
MOLE
WEIGHT
|
139.19 |
PHYSICAL
AND CHEMICAL PROPERTIES
|
PHYSICAL
STATE |
yellowish to brown crystals |
MELTING
POINT |
40 - 44 C |
BOILING
POINT |
113 C at 25
mmHg |
DENSITY
|
|
SOLUBILITY
IN WATER |
slightly soluble
(soluble in ethanol, ether, acetone, benzene,
slightly soluble in chloroform |
pH |
|
VAPOR
DENSITY |
|
REFRACTIVE
INDEX
|
|
FLASH
POINT |
90
C
|
STABILITY AND REACTIVITY |
STABILITY |
Stable
under normal conditions. |
INCOMPATIBILITIES
|
Strong oxidizing agents |
DECOMPOSITION PRODUCTS |
Carbon
oxides, Nitrogen oxides
|
POLYMERIZATION |
Has not been reported |
NFPA
RATINGS
|
Health Hazard: 1, Fire: 0, Reactivity Hazard: 0
|
SAFETY
|
HAZARD
NOTES |
Causes
burns. |
EYE
|
Causes eye burns. |
SKIN |
Causes skin burns. |
INGESTION |
Harmful if swallowed. Causes gastrointestinal tract burns. |
INHALATION |
Causes chemical burns to the respiratory tract. |
CHRONIC |
|
TRANSPORT
AND REGULATORY INFORMATION
|
UN
NO. |
3259
|
HAZARD CLASS |
8
|
PACKING GROUP |
III
|
HAZARD SYMBOL
|
C
|
RISK PHRASES |
22-34
|
SAFETY PHRASES |
23-24/25
|
DESCRIPTION
AND APPLICATION
|
Tropine is the tropane
core structure part (nitrogenous bicyclic nucleus) and tropic acid is the ester
part of atropine (a tropane alkaloid).
Atropine is hydrolysed to tropine and tropic
acid. Tropine also called tropanol (chemical designation: 8-Methyl-8-azabicyclo(3.2.1)octan-3-ol)
is an alcohol which forms esters. There are stereoisomers
endo- and exo- stereoisomers.
alpha-Tropanol |
CAS RN
|
120-29-6 |
Trivial name |
Tropine |
Systematic Name |
endo-8-Methyl-8-azabicyclo(3.2.1)octan-3-ol |
Melting point |
63 C |
Boiling point |
229 C |
Natural esters
|
Hyoscyamine, Atropine
|
beta-Tropanol |
CAS RN
|
135-97-7 |
Trivial name |
Pseudotropine |
Systematic Name |
exo-8-Methyl-8-azabicyclo(3.2.1)octan-3-ol |
Melting point |
108 -109 C |
Boiling point |
240 - 241 C |
Natural esters
|
Cocaine, Troparil |
Tropeine is an ester of tropine, either a natural alkaloid derived from plants or
semi-synthetic. The best known members of tropeine natural alkaloids are Hyoscyamine,
Atropine, Scopolamine, Ecgonine, Cocaine.
Tropinone,
bicyclic aminoketone, is a useful synthetic precursor
in the preparation of many tropane ring compounds including
tropine and atropine.
nor- is a chemical acronym and prefix
to describe the lacking of methyl chains that are
part of a larger molecule. Nortropine is a tropine compound lacking methyl chain
at nitrogen
carbon.
|
SALES
SPECIFICATION
|
APPEARANCE |
yellowish to brown crystals |
ASSAY
|
99.0%
min
|
MELTING
POINT |
40
- 44 C
|
|