alpha-TERPINEOL
Synonyms. alpha-Terpineol; 1-Menthene-8-ol; 1-Methyl-4-isopropyl-1-cyclohexen-8-ol; 1-Methyl-4-isopropyl-1-cyclohexene-8-ol; 1-p-Menthen-8-ol; 2-(4-Methyl-3-cyclohexenyl)-2-propanol; Carvomenthenol; Terpenol; Terpineol schlechthin; alpha,alpha-4-Trimethyl-3-cyclohexene-1-methanol; alpha-Terpinenol; DL-alpha-Terpineol; p-Menth-1-en-8-ol; Other RN:  2438-12-2, 22347-88-2

alpha-TERPINEOL
 

PRODUCT IDENTIFICATION

CAS RN

 98-55-5

EINECS RN

 202-680-6, 219-448-5

FORMULA

 C10H18O

MOLE WEIGHT

 154.25

H.S CODE

 2906.19.3000

SMILES

 C([C@@H]1CCC(C)=CC1)(C)(C)O

CLASSIFICATION

Flavor, Monoterpene

EXTRA NOTES

 FEMA No. 3045

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

 clear to slightly yellow liquid

MELTING POINT

 18 C

BOILING POINT

 220 C

DENSITY

0.933

SOLUBILITY IN WATER

710 mg/l
SOLVENT SOLUBILITY Soluble in organic solvents

VAPOR DENSITY

 

log P(octanol-water)

 2.98

VAPOR PRESSURE

 0.0423

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 1.482 - 1.485

FLASH POINT

90 C

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents
DECOMPOSITION PRODUCTS

Carbon oxides.
POLYMERIZATION

Has not been reported

NFPA RATINGS

Health Hazard: 1, Fire: 2, Reactivity Hazard: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Terpineol

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - alpha-Terpineol

PubChem Compound Summary - alpha-Terpineol

IPCS INCHEM -  alpha-Terpineol

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  alpha-Terpineol

http://www.ebi.ac.uk/chebi/ -  alpha-Terpineol

http://www.ncbi.nlm.nih.gov/ -  alpha-Terpineol

Material Safety Data Sheet

http://www.thegoodscentscompany.com/

http://www.leffingwell.com/

http://ar.iiarjournals.org/
Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity. Materials and Methods: The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. Results: The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-κB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-κB translocation and activity using two NF-κB assays, and by the down-regulation of the expression of several NF-κB-related genes such as IL-1β and IL1R1. Conclusion: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-κB pathway.

 

SALES SPECIFICATION

APPEARANCE

 clear to slightly yellow liquid

PURITY

97.0% min

REFRACTIVE INDEX

 1.478 - 1.490

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD SYMBOL

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Harmful by ingestion. This substance has caused adverse reproductive and fetal effects in animals.

GHS

  

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H315 H319 H335

P STATEMENTS

P261 P305+P351 H338
EC DIRECTIVES

 
HAZARD CODES

Xi Irritant

RISK PHRASES

36/37/38

SAFETY PHRASES

 26-36

 

PACKING

 

 

PRICE INFORMATION