PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

CLASSIFICATION

Fragrance, Perfume ingredient, Synthetic musk

EXTRA NOTES

FEMA No. 2840
Flavis number 10.004
Synthetic musk odor

PHYSICAL AND CHEMICAL PROPERTIES

MELTING POINT

SOLUBILITY IN WATER

REFRACTIVE INDEX

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Synthetic musk

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Oxacyclohexadecan-2-one

PubChem Compound Summary - Exaltolide

http://www.ebi.ac.uk/ -  Exaltolide

http://www.ncbi.nlm.nih.gov/ -  Exaltolide

Material Safety Data Sheet

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Exaltolide

Local:
Musk: any of various powerful-smelling substances obtained originally from the musk glands of male musk deer during the mating season for sexual attraction or from certain animals such as otter or civet. It is used in perfume as a scent and fixative. It is obviously the first importance in perfumery as it features the better properties in not only penetration but also persistency than any other known substance. It scents huge space without even small loss of weight. But synthetic musks should replace for natural must to protect animals. Muscone, 3-Methylcyclopentadecanone, is the major constituent of natural musk. The odoriferous nucleus of natural musk is the C-16 cyclic ketone (cyclopentadecanone). But synthetic musklile products are based on the symmetry of the three nitro groups or on polycyclic and cyclopentadecanone structure.

The synthetic musklike products include:

• Nitro Class
• Musk Xylol  (2,4,6-Trinitro-1,3-dimethyl-5-tert-butylbenzene, CAS RN: 81-15-2 )
• Musk Ketone (4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone, CAS RN: 81-14-1 )
• Musk Ambrette (4-tert-Butyl-2,6-dinitro-3-methoxytoluene, CAS RN: 83-66-9)
• Musk Tibetene (5-tert-Butyl-1,2,3-trimethyl-4,6-dinitrobenzene, CAS RN: 145-39-1 )
• Musk Moskene (2,3-Dihydro-1,1,3,3,5-pentamethyl-4,6-dinitro-1H-Indene, CAS RN: 116-66-5)
• Polycyclic Musk Class
• Musk GX (1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopryan, CAS RN: 1222-05-5 )
• 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (CAS RN: 1506-02-1)
• Celestolide (4-Acetyl-6-t-butyl-1,1-dimethylindan, CAS RN: 13171-00-1)
• 5-Acetyl-1,1,2,3,3,6-hexamethyl indan (CAS RN: 15323-35-0)
• 5-Acetyl-3-isopropyl-1,1,2,6-tetramethylindane (CAS RN: 68140-48-7)
• 1,1,4,4-Tetramethyl-6-ethyl-7-acetyl-1,2,3,4-tetrahydronaphthalene (CAS RN: 88-29-9)
• 3,4,6,7,8,9-Hexahydro-4,6,6,9,9-pentamethyl-1H-naphtho[2,3-C]pyran (CAS RN: 1922-67-4)
• 2,4-Dimethyl-2-(1,1,4,4-tetramethyltetralin-6-yl)-1,3-dioxolane (CAS RN: 131812-67-4)
• Macrocyclic Class
• Muscone (3-Methylcyclopentadecanone CAS RN: 541-91-3)
• Exaltone (Cyclopentadecanone, CAS RN: 502-72-7)
• Cervolide (1,6-Dioxacycloheptadecan-7-one, CAS RN: 6707-60-4)
• Musk Ambrettolide ((Z)-Oxacycloheptadec-8-en-2-one, CS RN: 123-69-3)
• Exaltolide (Oxacyclohexadecan-2-one, CAS RN: 106-02-5)
• Musk T (1,4-Dioxacycloheptadecane-5,17-dione, CAS RN: 105-95-3)
• Ambrettolide (Oxacycloheptadec-10-en-2-one, CAS RN: 28645-51-4)
• Civetone ((Z)-9-Cycloheptadecen-1-one, CAS RN: 542-46-1)
• Cyclopentadecanone (CAS RN: 502-72-7)
• Ambretone (5-Cyclohexadecenone, CAS RN:37609-25-9)
• Musk R1 (11-Oxahexadecanolide, CAS RN: 3391-83-1 )
• 1,4-Dioxacyclohexadecane-5,16-dione (CAS RN: 54982-83-1)

APPEARANCE

MELTING POINT

34 - 38 C

HAZARD OVERVIEW

May cause eye and skin irritation. May cause respiratory and digestive tract irritation. 

RISK PHRASES

SAFETY PHRASES

24/25