ETIDRONIC ACID, TETRASODIUM SALT

PRODUCT IDENTIFICATION

CAS NO. 3794-83-0

ETIDRONIC ACID, TETRASODIUM SALT

EINECS NO. 223-267-7
FORMULA C2H4Na4O7P2
MOL WT. 293.96
H.S. CODE  
TOXICITY  
SYNONYMS 1-Hydroxyethane-1,1-diphosphonic acid , Tetrasodium salt;
1-Hydroxyethylidene-1,1-diphosphonic acid, Tetrasodium salt; Sodium HEDP; HEDPS; 1-hydroxyethylidenedi(phosphonic acid), Tetrasodium salt; (Hydroxyethylidene) diphosphonic acid, Tetrasodium salt;

CLASSIFICATION

PHOSPHONATES /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

clear to yellow liquid

MELTING POINT -5 C
BOILING POINT  
SPECIFIC GRAVITY 1.30 - 1.35
SOLUBILITY IN WATER

miscible

AUTOIGNITION  
pH 10 - 12
VAPOR DENSITY  
NFPA RATINGS Health: 3; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions.

APPLICATIONS

Phosphonates derived from phosphorous (phosphonic) acid are employed in the applications of scale Inhibition, sequestration, dispersion and corrosion inhibition in addition to the main applications of agricultural chemicals such as fertilizers, pesticides, and soil conditioners. Phosphonates offer a wide range of sequestrants to control metal ions in aqueous systems. By forming stable water soluble complexes with multivalent metal ions, phosphonates prevent undesired interaction by blocking normal reactivity of metal ions. This ability contributes to function as threshold industrial water treatment and metal treatment processes (antiscalants, corrosion inhibitors, chelants, sludge conditioners, pulp bleachings, deflocculants, dispersants, metal cleaners, electroplating and crystal growth modifiers). Phosphonates are also used in manufacturing detergents, cosmetics and personal care products for special functions such as low levels iron control, stain removal, bleach stabilization, peroxide stabilization and anti-encrustation. Phosphonates existing in various compounds as acids or salts are marketed in the form of concentrated solutions.
SALES SPECIFICATION

APPEARANCE

clear to yellow viscous liquid

ACTIVE ACID

25.0% min

ACTIVE SALT

35.0% min

CHLORIDE

1.0% max

IRON

35ppm max

TRANSPORTATION
PACKING  
HAZARD CLASS 8 (Packing Group: III )
UN NO. 1760
OTHER INFORMATION
Hazard Symbols: C, Risk Phrases: 10/35, Safety Phrases: 9/16/23/26/28A/33/36

PHARMACEUTICAL APPLICATION OF BIPHOSPHONATE

Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as osteoporosis, metastatic disease, and Paget's disease. While bisphosphonates are analogues of endogenous pyrophosphate structurally, they are characterized by a P-C-P bond, the linking oxygen is replaced with a carbon, which is resistant to enzymatic and chemical hydrolysis. General structure is

Bisphosphonate

Side chains are responsible for chemical-physicla properties, mechanism of resorption, and pharmacokinetics. It is known that biphosphonates bind strongly to hydroxyapatite crystals at the sites of increased bone turnover preferentially and inhibit the formation, aggregation, and dissolution of the crystals.They also may inhibit osteoclast function directly, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation.
Bisphosphonate products include: (see belows)

  • Etidronic acid (CAS #: 2809-21-4)
  • Clodronic acid (CAS #: 10596-23-3)
  • Tiludronic acid (CAS #: 89987-06-4)
  • Medronic acid (CAS #: 1984-15-2)
  • Pamidronic acid (CAS #: 40391-99-9)
  • Neridronic acid (CAS #: 79778-41-9)
  • Olpadronic acid (CAS #: 63132-39-8)
  • Alendronic acid (CAS #: 66376-36-1)
  • Ibandronic acid (CAS #: 114084-78-5)
  • Risedronic acid (CAS #: 105462-24-6)
  • Zoledronic Acid (CAS #: 118072-93-8)

 

Biphosphonate
(Sosium salt)

CAS #

Side Chains
(R1, R2)

STRUCTURE

Alendronic acid
(Alendronate)
66376-36-1

R1= -OH
R2= -C
3H6NH2

Alendronic acid

Clodronic acid
(Clodronate)
10596-23-3

R1= -Cl
R2= -Cl

Clodronic acid

Etidronic acid
(Etidronate)
2809-21-4

R1= -OH
R2= -CH
3

Etidronic acid

Ibandronic acid
(Ibandronate)
114084-78-5

R1= -OH
R2= -C
2H4N(CH3)C5H11

Ibandronic acid

Medronic acid
(Medronate)
1984-15-2

R1= -H
R2= -H

Medronic acid

Neridronic acid
(Neridronate)
79778-41-9

R1= -OH
R2= -C
5H10NH2

Neridronic acid

Olpadronic acid
(Olpadronate)
63132-39-8

R1= -OH
R2= -C
2H4N(CH3)2

Olpadronic acid

Pamidronic acid
(Pamidronate)
40391-99-9

R1= -OH
R2= -C
2H4NH2

Pamidronic acid

Risedronic acid
(Risedronate)
105462-24-6

R1= -OH
R2= Risedronic acid R2

Risedronic acid

Tiludronic acid
(Tiludronate)
89987-06-4

R1= -H
R2= -S-CH
4Cl

Tiludronic acid

Zoledronic Acid
(Zoldronate)
118072-93-8

R1= -OH
R2= Zoledronic Acid R2

Zoledronic Acid




PRICE INFORMATION

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