n-HEXADECYLTRIMETHYLAMMONIUM CHLORIDE (CETRIMONIUM CHLORIDE)

'Phase transfer catalysis (PTC)' methodology is a powerful tool improving process efficiency, product selectivity and providing mild reaction conditions in organic chemical reactions. In many chemical reaction situations, there are different species (immiscible liquids or solid and liquid) which don't react each othrer due to separattion by an interface. Small quantity of ��phase-transfer catalyst��, involves a substrate (soluble in the organic layer) and an anionic reagent or a nucleophile (dissolved in the aqueous layer), extracts one of the reactants, most commonly an anion, across the interface into the other phase where reaction can take place with the substrate and reaction can proceed. The quaternary ammonium salts can carry the nucleophile from the aqueous to organic phase and are used as the most commonly used as phase-transfer catalyst. The phosphonium derivatives favoring higher thermal stability property are also used. Crown ethers and polyethylenglycol compounds are also widely used in this application.

N-HEXADECYLTRIMETHYLAMMONIUM CHLORIDE
PRODUCT IDENTIFICATION
CAS NO.	112-02-7
EINECS NO.	203-928-6
FORMULA	CH₃(CH₂)₁₅N(Cl)(CH₃)₃
MOL WT.	320.00
H.S. CODE	2923.90
TOXICITY
SYNONYMS	Cetyltrimethylammonium Chloride;
1-Hexadecanaminium, N,N,N-trimethyl-, chloride; Cetrimonium chloride; C16-alkyltrimethylammonium chloride; Hexadecanaminium, N,N,N-trimethyl-, chloride; Cetyl Trimethyl Ammonium Chlride; Cetrimonium Chloride;
SMILES
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	Clear mobile liquid
MELTING POINT
BOILING POINT	100 C
SPECIFIC GRAVITY
SOLUBILITY IN WATER	soluble
pH	6 - 9
VAPOR DENSITY
REFRACTIVE INDEX
NFPA RATINGS	Health: 2; Flammability: 0; Reactivity: 0
FLASH POINT
STABILITY	Stable under ordinary conditions
GENERAL DESCRIPTION & APPLICATIONS
Quaternary ammonium compounds are any of a group of ammonium salts in which organic radicals have been substituted for all four hydrogens of the original ammonium cation. They has a central nitrogen atom which is joined to four organic radicals and one acid radical. The organic radicals may be alkyl, aryl, or aralkyl, and the nitrogen can be part of a ring system. They are prepared by treatment of an amine with an alkylating agent. They show a variety of physical, chemical, and biological properties and most compounds are soluble in water and strong electrolytes. Such compounds include Benzalkonium Chloride ( CAS RN: 8001-54-5) Benzethonium Chloride CAS 121-54-0 Cetalkonium Chloride( CAS 122-18-9) Cetrimide ( CAS 8044-71-1) Cetrimonium Bromide ( CAS 57-09-0) Cetylpyridinium Chloride (CAS 123-03-5) Stearalkonium Chloride ( CAS 122-19-0) They have properties of disrupting micro-organisms' cell processes and surfactants. These compounds are used as Active Ingredient for Conditioners Antistatic Agent Detergent Sanitisers Softner for textiles and paper products Phase Transfer Catalyst Antimicrobials Disinfection Agents And Sanitizers Slimicidal Agents Algaecide Emulsifying Agents Pigment Dispersers
SALES SPECIFICATION
BASE
APPEARANCE	white crystalline powder
ASSAY	99.0% min
30% SOLUTION
APPEARANCE	Clear mobile liquid
ACTIVE CONTENT	28% min
pH	6.0 - 8.0
WATER	70.0 - 72.0%
FREE AMINE	0.8% max
FREE AMINE HCl	0.8% max
TRANSPORTATION
PACKING	200kgs in Drum
HAZARD CLASS	8(9.2)
UN NO.	1759
GENERAL DESCRIPTION OF PHASE TRANSFER CATALYSIS
'Phase transfer catalysis (PTC)' methodology is a powerful tool improving process efficiency, product selectivity and providing mild reaction conditions in organic chemical reactions. In many chemical reaction situations, there are different species (immiscible liquids or solid and liquid) which don't react each othrer due to separattion by an interface. Small quantity of ��phase-transfer catalyst��, involves a substrate (soluble in the organic layer) and an anionic reagent or a nucleophile (dissolved in the aqueous layer), extracts one of the reactants, most commonly an anion, across the interface into the other phase where reaction can take place with the substrate and reaction can proceed. The quaternary ammonium salts can carry the nucleophile from the aqueous to organic phase and are used as the most commonly used as phase-transfer catalyst. The phosphonium derivatives favoring higher thermal stability property are also used. Crown ethers and polyethylenglycol compounds are also widely used in this application.
OTHER INFORMATION
`Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 25-36/37/39-45`
GENERAL DESCRIPTION OF ANTISEPTIC AGENT
Antiseptic agent is a substance which kills or inhibits the growth of disease-causing bacteria and other microorganisms. It is essentially nontoxic to to be applied to the skin or mucous membranes. (Disinfectant including cresol, bleaching powder, and phenol is in general toxic to cells of the body). Common antiseptic agents are Benzalkonium Chloride, Cetrimide, Chlorhexidine, Hexachlorophene, Iodine Compounds, Mercury Compounds (Thimerosol), Alcohol and Hydrogen Peroxide, Hexamine Hippurate, Triclosan, Cetylpyridinium Chloride, And Dequalinium. Other substances which can be used for antiseptic purpose include Boric acid and volatile oils such as Methyl Salicylate. Hexachlorophene and Benzalkonium Chloride are used primarily in hand or face washes. Benzalkonium Chloride must not be applied to areas which have not been fully rinsed as it is inactivated by organic compounds. Benzalkonium application many include disinfecting instruments and preservativing drugs in low concentration form. Iodine compounds have the widest spectrum of antiinfectives against bacteria, fungi, spores, protozoa, viruses, and yeasts. Aqueous iodine are less effective than alcoholic solutions, but alcoholic component is drying and irritating to abraided skin. Povidone iodine is convenient to use as it is less irritating, but not as effective. Chlorhexidine is used as a safe antiseptic or disinfectant to apply to prevent body infection and in oral rinses for treating sore gums and mouth ulcers and preventing plaque on teeth. It is used in the form of acetate, gluconate or hydrochloride, either alone or in combination with others such as cetrimide. Cetrimide is an antiseptic agent with detergent properties. It has the wide spectrum of antiinfectives against bacteria and fungi. It is used as an ingredient of shampoos for treating seborrhoea and psoriasis. A very dilute solution can be applied topically for the relief of sore gums. Hippuric Acid, an amino acid glycine, is excreted from the body and is used in urinary system drugs. Hexamine hippurates is helpful for preventing and treating infections of the urinary system; it acts by being transformed to formaldehyde. Triclosan is a very popular antibacterial agent. It is used in hospitals for cleansing and disinfecting the skin of patients and surgeons. It is used in cosmetics, household goods and personal care products. It is also used in plastics and textiles for antibacterial activity purpose. Cetylpyridinium chloride is used in oral rinses for cleaning mouth and treating minor throat or mouth infections and teething problems. Dequalinium chloride is antiinfectives against bacteria and fungi. It is used in treating bacterial or fungal infections of mouth and throat.