BETAMETHASONE-17-VALERATE

PRODUCT IDENTIFICATION

CAS NO. 378-44-9 (Base)
2152-44-5 (
17-Valerate)

BETAMETHASONE-17-VALERATE

EINECS NO. 218-439-3
FORMULA C27H37FO6
MOL WT. 476.58

H.S. CODE

 

TOXICITY

 

SYNONYMS Bedermin; Betnesol-V; Betneval; Betamethasone valerate;
9-Fluoro-11(beta),17,21-trihydroxy-16(beta)-methyl-1,4-pregnadiene-3,20-dione-17-valerate; Betnovate; Bextasol; 17-Valerato de 9-fluoro-11á,17,21-trihidroxi-16á-metilpregna- 1,4-dieno-3,20-diona; 17-Valérate de 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-méthylprégna- 1,4-diène-3,20-dione;
PRICE U$3,500.- for 1kg

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White to off-white crystalline powder
MELTING POINT 192 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION  & APPLICATIONS

Betamethasone, a synthetic glucocorticoid, an analog of prednisolone derived from cortisol, having activity in replacement therapy for adrenal insufficiency and as an antiinflammatory and immunosuppressant. Betamethasone has the most powerful activity of corticosteroids with a slight mineralocorticoid activity. It is used to treat many conditions including dermatitis, arthritis, inflammatory bowel disease, reactive airways disease, and respiratory distress syndrome in preterm infants and pruritus in corticosteroid-responsive dermatoses. The chemical designation is 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione. Some esters and salts of betamethasone for intramuscular, intraarticular, intrasynovial, or intralesional injection include:
  • Betamethasone acetate (CAS RN: 987-24-6): The acetate ester of betamethasone; white to off-white crystalline powder; for intramuscular, intraarticular, intrasynovial, or intralesional injection typically in combination with betnesol.
  • Betnesol (Betamethasone disodium phosphate, CAS RN: 151-73-5): The disodium salt of the 21-phosphate ester of betamethasone; very hygroscopic white to off-white powder; for intramuscular, intraarticular, intrasynovial, or intralesional injection in combination with betamethasone acetate.
  • Betamethasone-17-valerate (CAS RN: 2152-44-5); The 17-valerate ester of betamethasone, for the use of topical inflammation relief and for dermatologic.
  • Betamethasone-21-valerate (CAS RN: 2240-28-0); The 21-valerate ester of betamethasone, for the use of topical inflammation relief and for dermatologic.
  • Betamethasone 17,21-divalerate (CAS RN: 38196-44-0): The 17,21-Divalerate ester of betamethasone, used topically for the relief of inflammation and pruritus in corticosteroid-responsive dermatoses.
  • Betamethasone butyrate propionate (CAS RN: 5534-02-1)
  • Betamethasone acibutate (CAS RN: 5534-05-4)
  • Betamethasone-21-butyrate (CAS RN: 56933-60-9)
  • Betamethasone-21-propionate (CAS RN: 75883-07-7)
  • Betamethasone 17,21-dipropionate (CAS RN: 5593-20-4)
  • Betamethasone benzoate
SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

Complies

ASSAY

97.0 - 103.0%

OPTICAL ROTATION

+75° ~ +82°

INDIVIDUAL IMPURITY

0.5% max
(Betamethasone: 0.5% max, Betamethasone 21 Valerate: 0.5% max)

LOSS ON DRYING

0.5.% max

RESIDUE ON IGNITION

0.2% max

SOLVENT RESIDUE

0.1% max

TRANSPORTATION
PACKING

 

HAZARD CLASS 6.2 (Packing Group: III)
UN NO. 2811
OTHER INFORMATION
European Hazard Symbols: XN, Risk Phrases: 48, Safety Phrases: 22-24/25

GENERAL DESCRIPTION OF CORTICOSTEROID

Corticosteroid is a synthetic or naturally occurring 21-carbon steroid structure substances with four fused rings and vary functional branches attached to the ring system. Cholesterol and steroid hormones have this carbon skeleton. The term steroid refers to these three groups that contain a hydrogenated cyclopentano perhydro phenanthrene ring system. In restricted context for medical usage by non-endocrinologists, it refers to corticosteroids. Natural corticosteroids are elaborated by the adrenal cortex in response to physiological carbohydrate metabolism. According to their predominant biologic activity, they are divided into two major groups: glucocorticoid and mineralocorticoid. Glucocorticoid's chief function is to regulate carbohydrate, lipid, and protein metabolism and inhibit the release of ACTH (adrenocorticotropic hormone). Glucocorticoids also affect muscle tone and the microcirculation, participate in the maintenance of arterial blood pressure, increase gastric secretion, alter connective tissue response to injury, impede cartilage production, inhibit inflammatory, allergic, and immunologic responses, invoke shrinkage of lymphatic tissue, reduce the number of circulating lymphocytes, and affect the functions of the central nervous system. In humans, the most important ones are cortisol, cortisone, and corticosterone. Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water and promote retention of sodium, loss of potassium. Aldosterone plays a role also in promoting tissue repair. Spironolactone is the aldosterone antagonist called potassium-sparing diuretic used in the treatment of hypertension. Corticosteroids are used in clinically for hormonal replacement therapy, for suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory agents, and to suppress immune responses.
  • Glucocorticoid Receptor Agonists
    • Dexamethasone
    • Triamcinolone
    • Hydrocortisone
    • Prednisone
  • Glucocorticoid Receptor Antagonists
    • Mifepristone
    • Onapristone
  • Mineralocorticoid Receptor Agonists
    • Aldosterone
  • Mineralocorticoid Receptor Antagonists
    • Spironolactone
    • Eplerenone
PRICE INFORMATION

Click to open the table