CALCITRIOL (1,25-DIHYDROXYCHOLECALCIFEROL)

CALCITRIOL

PRODUCT IDENTIFICATION

CAS NO.

32222-06-3; 125338-24-1

CALCITRIOL

EINECS NO. 250-963-8

FORMULA C₂₇H₄₄O₃

MOL WT. 416.64

H.S. CODE

TOXICITY

SYNONYMS 1,25-Dihydroxycholecalciferol; 1-alpha,25-Dihydroxycholecalciferol;

(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol; 1alpha,25-Dihydroxyvitamin D3; (1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; Dihydroxyvitamin D3; Calcitriolum; 9,10-Seco(5Z,7E)-5,7,10(19)-cholestatriene-1alpha,3beta,25-triol; 1-alpha,25-Dihydroxyvitamin D3; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aS)-1-[(2R)-6- hydroxy-6-methyl-heptan-2-yl]-7a- methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]- 4-methylidene-cyclohexane-1,3-diol;

DERIVATION

CLASSIFICATION

VITAMINS / BONE DENSITY REGULATORS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder

MELTING POINT

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER Insoluble

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Calcitriol, 1,25-dihydroxycholecalciferol, is the physiologically active form of vitamin D which contributes to the intestinal absorption of Ca²⁺ and Ca²⁺ resorption by bone. Calcitriol is a steroid hormone found in the body. Calcitriol is used as a medication in the treatment of hypocalcaemia, hypophosphatemia, rickets, and osteoporosis. Calcifediol (25-hydroxycholecalciferol) is a prehormone which is produced by the metabolism of cholecalciferol. Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcifediol is converted by the kidneys into calcitriol and calcitriol is converted into alfacalcidol in the liver.

Bone Density Regulators	CAS RN
Alendronate sodium	121268-17-5
Alendronic acid	66376-36-1
Alfacalcidol	41294-56-8
Calcifediol	63283-36-3
Calcitonin	47931-85-1
Calcitriol	32222-06-3
Cholecalciferol	67-97-0
Clodronic acid	10596-23-3
Dihydrotachysterol	67-96-9
Disodium cycloheptylaminomethylenediphosphonate	138330-18-4
Ergocalciferol	50-14-6
Etidronate Disodium	7414-83-7
Etidronic acid	2809-21-4
Gallium nitrate	135886-70-3
Hydroxycholecalciferols
Ibandronate sodium hydrate	138926-19-9
Ibandronic acid	114084-78-5
Olpadronic acid	63132-39-8
Oxidronic acid	15468-10-7
Pamidronate disodium	109552-15-0
Pamidronic acid disodium salt	57248-88-1
Pamidronic acid	40391-99-9
Potassium phosphate dibasic	7758-11-4
Procalcitonin	56645-65-9
Raloxifene	84449-90-1
Risedronate sodium	115436-72-1
Risedronic acid	105462-24-6
Secalciferol	55721-11-4
Tamoxifen	10540-29-1
Teriparatide	52232-67-4
Tiludronic acid	89987-06-4
Toremifene citrate	89778-27-8
Toremifene	89778-26-7
Vitamin D	1406-16-2
Vitamin D2 sulfate	1784-46-9
Zoledronic acid	118072-93-8
24,25-Dihydroxyvitamin D 3	40013-87-4
25-Hydroxyvitamin D 2	21343-40-8

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION Conform to Test A (IR absorption), B (HPLC)

ASSAY

97.0 - 103.0%

RELATED SUBSTANCES 1beta, 25-Dihydroxy-vitamin D3: 0.5% max
1alpha, 25-Dihydroxy-trans-vitamin D3: 0.5% max
Pre-calcitriol: 0.5% max
Individual unspecified substances: 0.1% max
Total related substances: 1.0% max
Acetone: 5000ppm max

SOLVENT RESIDUES Dichloromethane: 0.06% max
Methanol: 0.3% max
Other residual solvent: 0.1% max

TRANSPORTATION

PACKING

HAZARD CLASS 6.1 (Packing Group: I)

UN NO. 2811

OTHER INFORMATION

Hazard Symbols: T+, Risk Phrases:26/27/28-63, Safety Phrases: 36/37/39-45

PRICE INFORMATION