CLIOQUINOL (IODOCHLORHYDROXYQUIN)

CLIOQUINOL

PRODUCT IDENTIFICATION

CAS NO.

130-26-7; 22112-03-4

CLIOQUINOL

EINECS NO. 204-984-4

FORMULA C₉H₅ClINO

MOL WT. 305.50

H.S. CODE

TOXICITY

Oral rat LD50: 5gm/kg

SYNONYMS Chloro-8-hydroxyiodoquinoline; Quinoform; Quinambicide;

Iodochlorhydroxyquin; Iodochlorhydroxyquinol; Iodochlorhydroxyquinoline; Iodochlorohydroxyquin; Iodochlorohydroxyquinoline; Iodochloroquine; Iodochloroxine; Iodochloroxychinolinum; Iodochloroxyquinoline; Iodoenterol; Iodoxyquinoline; 5-Chlor-7-jod-8-hydroxy-chinolin; 5-Chloro-7-iodo-8-hydroxyquinoline; 5-Chloro-7-iodo-8-quinolinol; 5-Chloro-8-hydroxy-7-iodoquinoline; 7-Iodo-5-chloro-8-hydroxyquinoline; 7-Iodo-5-chloroxine; Barquinol; Budoform; Chinoformum; Chloro-8-hydroxyiodoquinoline; Chloroiodoquin; Chloroiodoquine; Chlorojodochin; Cifoform; Cliochinolo; 5-Chloro-7-iodo-quinolin-8-ol;

DERIVATION

CLASSIFICATION

8-QUINOLINOLS / ANTISEPTICS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow to brown crystalline powder

MELTING POINT 173 - 179 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER (Freely soluble in DMF, pyridine)

VAPOR DENSITY

REFRACTIVE INDEX

NFPA RATINGS

AUTOIGNITION

FLASH POINT

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION OF QUINOLINE & APPLICATIONS

Clioquinol is one of the halogenated 8-quinolinols which are antibacterial, intestinal antiamebic, and vaginal trichomonacide agents. They are derived from 8-hydroxyquinoline, an antiseptic agent with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. Clioquinol, iodochlorohydroxyquinoline, is an antifungal with antieczematic and antipruritic properties. Clioquinol topical preparations are used to treat skin infections. It was administered orally in the treatment of amebic dysentery. The oral preparation is banned worldwide due to associated subacute myelo-optic neuropathy. Chlorquinaldol, 5,7-dichloro-2-methyl-8-hydroxyquinoline, has antibacterial, antifungal and amoebicidal activity with antieczematic and antipruritic properties; used topically in the treatment of cutaneous and vaginal infections. It is a similar agent to clioquinol.

SALES SPECIFICATION

APPEARANCE

yellow to brown crystalline powder

CONTENT

97.0 - 103.0%

RELATED SUBSTANCE

3.0% max

FREE IODINE

Nil

HALOGEN ION

0.5% max

SULFATED ASH

0.2% max

LOSS ON DRYING

0.5% max

MELTING POINT

173 - 179 C

TRANSPORTATION

PACKING

25kgs in fiber drum

HAZARD CLASS

UN NO.

OTHER INFORMATION

Hazard Symbols: XN, Risk Phrases:22-36/37/38, Safety Phrases: 26-36

PRICE INFORMATION