QUINUCLIDINE

PRODUCT IDENTIFICATION

CAS NO. 100-76-5

QUINUCLIDINE

EINECS NO. 202-887-1
FORMULA C7H13N
MOL WT. 111.18

H.S. CODE

 

TOXICITY

 
SYNONYMS 1-Azabicyclo[2.2.2]octane;
1,4-Ethylidinepiperidine; 1,4-Ethanopiperidine; Chinuclidin;
DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT 157 - 160 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

Health: 3, Flammability: 0, Reactivity: 1

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

APPLICATIONS

Quinuclidine is a part of the Cinchona alkaloid molecules. It is a tertiary amine of bicyclic ring bridged with N. Single-cyclic amines such as piperidines, collidines are secondary amines. Quinuclidine dominates important features of cinchona alkaloids due to its strong basicity and chirality. Basicity of quinuclidine is much stronger than piperidines and collidines. Ring system compounds with nitrogen which have basic property play important roles in pharmaceuticals. Quinuclidine chirality is useful as a bioorganic catalysts. Quinuclidines are very biologically active compounds. Some quinuclidines are listed in CWC ( Chemical Weapons Convention) schedule 2 substances which may not be exported as they are biologically toxic and are precursors of other listed substances.
SALES SPECIFICATION

APPEARANCE

white to yellowish crystalline powder

ASSAY

97.0% min

MELTING POINT 157 - 160 C
TRANSPORTATION
PACKING
 
HAZARD CLASS 61. (Packing Group: II)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 24/25-38-41, Safety Phrases: 26-36/37/39-45
BASICITY STRENGTH OF SOME AMINES

Amidines ( -HN=CNH2) and guanidines [-HN=C(NH2)2] are strongly basic reagents. Bases activation of deprotonation is the first step in the synthesis. The strength of basicity, nucleophilicity, steric hindrance or solubility are the factors to select reagents for the best results in the chemical reactions such as alkylation, tautomerization, dehydrohalogenation, michael-addition, esterification, saponification, acylation, silylations, aldol-condensation, eliminations, and cyclization. The order of basicity strength of some amines are; TBD > MTBD > DBU > DBN > TMG > Quinuclidine > TMP, Pempidine > Triethylamine > TED > Tributylamine > Collidine > Lutidine

  • TBD: 1,5,7-Triazabicyclo(4.4.0)dec-5-ene; 1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a] pyrimidine, CAS #: 5807-14-7
  • MTBD :7-Methyl-1,5,7-triazabicyclo(4.4.0)dec-5-ene;1,3,4,6,7,8-Hexahydro-1- methyl-2H-pyrimido [1,2-a]pyrimidine, CAS #: 84030-20-6
  • DBU: 1,8-Diazabicyclo[5.4.0]undec-7-ene; 2,3,4,6,7,8,9,10-Octahydropyrimidol[1,2-a] azepine, CAS #: 6674-22-2
  • DBN: 1,5-Diazabicyclo[4.3.0]non-5-ene, CAS #: 3001-72-7
  • TMG: 1,1,3,3-Tetramethylguanidine; N,N,N',N'-Tetramethylguanidine, CAS #: 80-70-6
  • Quinuclidine: 1-Azabicyclo[2.2.2]octane, CAS #: 100-76-5
  • TMP: 2,2,6,6-Tetramethylpiperidine, CAS #: 768-66-1
  • Pempidine: 1,2,2,6,6-Pentamethylpiperidine, CAS #: 79-55-0
  • TED: 1,4-Diazabicyclo[2.2.2]octan; Triethylenediamine, CAS #: 280-57-9
  • Collidine: Trimethylpyridine, CAS #: 108-75-8 (2,4,6- Isomer)
  • Lutidine: Dimethylpyridine, CAS #: 108-48-5 (2,6- Isomer)
PRICES

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