STAVUDINE (3'-DEOXY-2',3'-DIDEHYDROTHYMIDINE)

STAVUDINE
PRODUCT IDENTIFICATION
CAS NO.	3056-17-5; 132425-31-1
EINECS NO.
FORMULA	C₁₅H₁₄N₄O
MOL WT.	266.30
H.S. CODE
TOXICITY
SYNONYMS	Estavudina; d 4T (nucleoside); d4T; Stavudine; Stavudinum;
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine; 2',3'-Didehydro-3'-deoxythymidine; 3'-Deoxy-2',3'-didehydrothymidine; Zerit; Zerut XR;
SMILES
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT	161 - 166 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Soluble (sparingly soluble in acetone, slightly soluble in lower alcohol)
pH
VAPOR DENSITY
REFRACTIVE INDEX
NFPA RATINGS	Health: 1; Flammability: 1; Reactivity: 0
AUTOIGNITION
FLASH POINT
STABILITY	Stable under normal conditions.
GENERAL DESCRIPTION & APPLICATIONS
Stavudine is a nucleoside analogue of thymidine that inhibits reverse transcriptase and has in vitro activity against human immunodeficiency virus (HIV). It is a white to off-white crystalline powder; melting point 161 - 166 C; soluble in water, sparingly soluble in acetone, slightly soluble in lower alcohol (methanol, ethanol, isopropanol). The chemical designation is (2'-3'-didehydro-2'-3'-dideoxythymidine ( shortly d4T). Reverse transcriptase is an enzyme that can transcribe RNA into DNA to copy genetic information from RNA to DNA, therefore also called RNA-directed DNA polymerase. Reverse transcriptase inhibitor is an antiretroviral agent that blocks activity of the reverse transcriptase of a retrovirus. Every retrovirus has a reverse transcriptase enzyme which transcribes the genetic information from its RNA into DNA. Protease inhibitors are the second class of antiretroviral drugs for the treatment of HIV. Aantiretroviral agents Non-nucleoside reverse transcriptase inhibitors Delavirdine [CAS #: 136817-59-9] Delavirdine mesylate [CAS #: 147221-93-0] Efavirenz [CAS #: 154598-52-4] Nevirapine [CAS #: 129618-40-2] Nucleoside/Nucleotide reverse transcriptase inhibitors Abacavir [CAS #: 136470-78-5] Abacavir succinate [CAS #: 168146-84-7] Abacavir sulfate [CAS #: 188062-50-2] Adefovir [CAS #: 106941-25-7] Adefovir dipivoxil [CAS #: 142340-99-6] Combivir (Lamivudine/Zidovudine mixture) [CAS #: 165456-81-5] Didanosine [CAS #: 69655-05-6] Emtricitabine [CAS #: 143491-57-0] Lamivudine [CAS #: 134678-17-4] Lamivudine sulfoxide [CAS #: 160552-55-6] Pradefovir mesylate [CAS #: 625095-61-6] Stampidine [CAS #: 217178-62-6] Stavudine [CAS #: 3056-17-5] Tenofovir [CAS #: 147127-20-6] Tenofovir disoproxil [CAS #: 201341-05-1] Tenofovir Disoproxil Fumarate [CAS #: 202138-50-9] Trizivir (Abacavir sulfate/Lamivudine/Zidovudine mixture) [CAS #: 364057-50-1] Zalcitabine [CAS #: 7481-89-2] Zidovudine [CAS #: 30516-87-1] Zidovudine sodium salt [CAS #: 106060-86-0] Protease inhibitors Amprenavir [CAS #: 161814-49-9] Atazanavir [CAS #: 198904-31-3] Atazanavir sulfate [CAS #: 229975-97-7] Fosamprenavir [CAS #: 226700-79-4] Fosamprenavir calcium [CAS #: 226700-81-8] Fosamprenavir sodium [CAS #: 226700-80-7] Indinavir [CAS #: 150378-17-9] Indinavir hydrate [CAS #: 180683-37-8] Indinavir Sulfate [CAS #: 157810-81-6] Kaletra (Lopinavir/Ritonavir mixture) [CAS #: 369372-47-4] Lopinavir [CAS #: 192725-17-0 Nelfinavir [CAS #: 159989-64-7] Nelfinavir mesylate [CAS #: 159989-65-8] Ritonavir [CAS #: 155213-67-5] Saquinavir [CAS #: 127779-20-8] Saquinavir mesylate [CAS #: 149845-06-7] Tipranavir [CAS #: 174484-41-4] Tipranavir disodium [CAS #: 191150-83-1]
SALES SPECIFICATION
APPEARANCE	white to off-white crystalline powder
IDENTIFICATION	pass Test A (UV), B (IR), C (HPLC)
ASSAY	98.0 - 102.0%
LOSS ON DRYING	0.5% max
RESIDUE ON IGNITION	0.2% max
HEAVY METALS	10ppm max
MELTING POINT	160 - 166 C
OPTICAL ROTATION	-46° ~ -40°
SOLVENT RESIDUE	MeOH 0.3% max Isopropanol 0.3% max Toluene 0.1% max
RELATED SUBSTANCES	Thymine 1.0% max thymidine 0.2% max Other Individual impurity 0.2% max Other total impurity 0.5% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
PRICE INFORMATION