QUININE

QUININE

PRODUCT IDENTIFICATION

CAS NO.

130-95-0 (Base)
130-89-2 (Hydrochloride)

(-)-QUININE

EINECS NO.

205-003-2

FORMULA C₂₀H₂₄N₂O₂

MOL WT. 324.42

H.S. CODE

TOXICITY

SYNONYMS Legatrin; Novoquinine; Strema;

6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol; 6'-Methoxycinchonan-9-ol; Quin-amino; Quinamm; Quindan; Quiphile;

SMILES

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder

MELTING POINT 173 - 175 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER slightly soluble

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS Health: 2; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions. Light sensitive.

GENERAL DESCRIPTION & APPLICATIONS

Quinine, Isolated originally from Cinchona succirubra, is a white crystalline alkaloid soluble in alcohol, ether, carbon disulfide, chloroform, and glycerol. It is almost insoluble in water. It is used chiefly (usually in the form of soluble hydrochloride or sulfate salts) in the treatment of falciparum malaria resistant to other antimalarials. Other anti-malaria drugs such as quinacrine, chloroquine, and primaquine are more effective, but murative malarial parasite developed resistance to them. Quinine is preferred where the disease has become highly resistant to other anti-malaria drugs. In addition to its anti-malarial activity, quinine shows anti-bacteria, antipyretic, mild oxytocic, local anesthetic, cardiosvascular stimulant, and analgesic properties, and it decreases the excitability of the motor endplate. Quinine is used to prevent cardiac arrythmias and is used in tonic beverages which are mixed with alcohols for bitter taste. Quinine is one of the most useful alkaloids for pharmaceutical purposes.

Quinine hydrochloride (or dihydrochloride): hydrochloride salt of quinine; administered intravenously; having the same actions and uses with the base
Quinine sulfate: sulfate salt of quinine; having the same actions and uses with the base; administered orally.

SALES SPECIFICATION (USP, BP)

APPEARANCE

white to off-white crystalline powder

ASSAY

98.0 % min (on anhydrous basis)

OPTICAL ROTATION

-163° ~ 170° (C=2% in EtOH)

TRANSPORTATION

PACKING

25kgs in fiber drum

HAZARD CLASS

UN NO. 3335

OTHER INFORMATION

Hazard Symbols: , Risk Phrases: , Safety Phrases: 22-36

GENERAL DESCRIPTION OF CINCHONA ALKALOIDS

Cinchona Alkaloids are important subgroup of the polycyclic beta-carboline alkaloids. They are isolated from cinchona trees. The major eight alkaloids which occur as four pairs of enantiomers having 2R,3S configuration and 2S,3R configuration respectively are shown below. They are used in food and beverage industry as a bitter additive. They are used for pharmaceutical purposes of antimalarial, antibacteria, local anesthetic, cardiosvascular stimulant, and analgesic activities. They are useful as chiral elements for asymmetric synthesis.

(+)-ISOMERS
CINCHONINE CAS NUMBER : 118-10-5 EINECS NUMBER : 204-234-6 OTHER NAME(S): (9S)-cinchonan-9-ol; Cinchonan-9-ol; ADDITIONAL INFORMATION -Melting Point: 258 - 260 C -Optical Roration: +228° (C=0.5 in EtOH)	C₁₉H₂₂N₂O (294.40)
QUINIDINE CAS NUMBER : 56-54-2 EINECS NUMBER : 200-279-0 OTHER NAME(S): 6'-methoxy-alpha-(5-vinyl-2-quinuclidinyl)- 4-quinolinemethanol; (9S)-6'-methoxycinchonan-9-ol; beta-quinidine; Cardioquin; Quindine; Quinicardine; Quinidex; ADDITIONAL INFORMATION -Melting Point: 166 - 169 C -Optical Roration: +265° (C=1 in EtOH)	C₂₀H₂₄N₂O₂(324.42)
DIHYDROCINCHONINE CAS NUMBER : 485-65-4 EINECS NUMBER : 207-621-8 OTHER NAME(S): (9S)-10,11-Dihydrocinchonan-9-ol; ADDITIONAL INFORMATION -Melting Point: 269 - 272 C -Optical Roration: +194° (C=0.5 in EtOH)	C₁₉H₂₄N₂O (296.4)
DIHYDROQUINIDINE CAS NUMBER : 1435-55-8 EINECS NUMBER : 215-862-5 OTHER NAME(S): (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol; hydroconchinine; Hydroquinidine; ADDITIONAL INFORMATION -Melting Point: 169 - 172 C -Optical Roration: +226° (C=2 in EtOH)	C₂₀H₂₆N₂O₂(326.4)
(-)-ISOMERS
CINCHONIDINE CAS NUMBER : 485-71-2 EINECS NUMBER : 207-622-3 OTHER NAME(S): (-)-Cinchonidine; (8alpha,9R)-cinchonan-9-ol; L-Cinchonidine; ADDITIONAL INFORMATION -Melting Point: 200 - 203 C -Optical Roration: -109.2° (C=1.5 in EtOH)	C₁₉H₂₂N₂O (294.40)
QUININE CAS NUMBER : 130-95-0 EINECS NUMBER : 205-003-2 OTHER NAME(S): 6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)- 4-quinolinemethanol; 6'-Methoxycinchonan-9-ol; Quin-amino; Quinamm; Quindan; Quiphile; Strema; ADDITIONAL INFORMATION -Melting Point: 173 - 175 C -Optical Roration: -165° (C=2 in EtOH)	C₂₀H₂₄N₂O₂(324.42)
DIHYDROCINCHONIDINE CAS NUMBER : EINECS NUMBER : OTHER NAME(S): ADDITIONAL INFORMATION -Melting Point: -Optical Roration:	C₁₉H₂₄N₂O (296.4)
DIHYDROQUININE CAS NUMBER : 522-66-7 EINECS NUMBER : 208-334-0 OTHER NAME(S): (8alpha,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol); Hydroquinine; ADDITIONAL INFORMATION -Melting Point: 173 - 175 C -Optical Roration: -148° (C=1 in EtOH)	C₂₀H₂₆N₂O₂(326.4)

PRICES