PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

CLASSIFICATION

Sodium Channel Modulator, Analgesic (non-narcotic), Anticonvulsant, Antimanic, Depressant, Peripheral Nervous System Agent, Psychotropic, Tranquilizing Agent

PHYSICAL AND CHEMICAL PROPERTIES

SOLVENT SOLUBILITY

Soluble in alcohol and in acetone

REFRACTIVE INDEX

Stable under ordinary conditions

GENERAL DESCRIPTION & EXTERNAL LINKS

Wikipedia Linking: http://en.wikipedia.org/wiki/Carbamazepine

http://www.nature.com/
Sodium channels can provide a route for a persistent influx of sodium ions into neurons. Over the past decade, it has emerged that sustained sodium influx can, in turn, trigger calcium ion influx, which produces axonal injury in neuroinflammatory disorders such as multiple sclerosis (MS). The development of sodium channel blockers as potential neuroprotectants in MS has proceeded rapidly, and two clinical trials are currently ongoing. The route from the laboratory to the clinic includes some complex turns, however, and a third trial was recently put on hold because of new data that suggested that sodium channel blockers might have multiple, complex actions. This article reviews the development of the concept of sodium channel blockers as neuroprotectants in MS, the path from laboratory to clinic, and the current status of research in this area..........

http://web.me.com/
Sodium channel blockers are in wide spread use for the treatment of pain, despite the fact that there actual mode of action is not fully understood. It has been shown that the use of some of these blockers cause side effects such as inhibiting calcium channels and thus neuronal signal transmission, and in the case of Lamotrigine unexplained death. Currently there are three types of sodium channel blockers in use for the treatment of neuropathic pain initially anticonvulsants as they reduce the synchronous firing of neurons. Carbamazepine (5H-dibenz[b,f]azepine-5-carboxamide) is used as the ‘first line’ treatment for the condition trigeminal neuralgia (TN), (3) a chroninc disorder of the trigeminal nerve, which is split into 3 divisions the Ophthalmic, Maxillary and Mandibular it causes debilitating paroxysmal form of facial pain and can be present within one or all three of the afor mentioned divisions of the trigeminal nerve. Carbamazepine is metabolised to Carbamazepine-10,11-epoxide which displays a neuralgic effect, its mode of action as an anti-convulsant is know but its mode of action for treatment of neuropathic pain is unkown.........

APPEARANCE

IDENTIFICATION

passes Test

ASSAY

97.0-103.0% (on the dry basis)

LOSS ON DRYING

0.5% max

RELATED SUBSTANCES

0.2% max (Individual), 0.5% max (total)

HEAVY METALS

20ppm max

SULFATED ASH

0.1% max

ACIDITY

0.5ml max

MELTING POINT

189-193 C