CHLORPROMAZINE

PRODUCT IDENTIFICATION
CAS NO. 50-53-3 (Base), 69-09-0 (HCl)

CHLORPROMAZINE

EINECS NO. 200-045-8, 200-701-3
FORMULA C17H19ClN2S
MOL WT. 318.86

H.S. CODE

  

TOXICITY

  
SYNONYMS 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine;
2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine; Chloractil; Chlorpromazinium chloride; 2-Chloro-10-(3-dimethylaminopropyl)-Phenothiazine; 2-Chloro-10-(3-dimethylamino propyl) phenothiazine;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 192 - 196 C (decomposes)
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions

GENERAL DESCRIPTION & APPLICATIONS
The term antipsychotic refers to a group of drugs effective in the treatment of psychosis including schizophrenic, paranoid, schizoaffective, bipolar disorder, and other psychotic disorders. Traditional antipsychotic agents have phenothiazine  structure chemically. Phenothiazinene drugs are adrenergic blocking agents. Their pharmacologic actions including central nervous system depression, prolongation and potentiation of the effects of narcotic and hypnotic drugs, hypotensive activity, and antispasmodic, antihistaminic, and antiemetic activity. Other chemcial structures for antipsychotic drugs are diverse, they include thioxanthene, butyrophenone, dibenzoxazepine, dihydroindolone, benzisoxazole, and diphenylbutylpiperidine. Antipsychotic agents bind to dopamine, histamine, muscarinic cholinergic, a-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is known to be responsible for their major effects such as not only antipsychotic action by blockade in the mesolimbic and mesocortical areas and and antiemetic effects by blockade in the chemoreceptor trigger zone of the medulla but also extrapyramidal side effects (dystonia, akathisia, parkinsonism, and tardive dyskinesia) by blockade in the basal ganglia and sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion, and constipation) by blockade of histamine, cholinergic, and adrenergic receptors. The antipsychotic agents may be divided by chemical group and and the decreased propensity of extrapyramidal side effects into two main groups and a new class which is being processed.
  • Typical Antipsychotic
    • Chlorpromazine (CAS #: 50-53-3, Phenothiazine with aliphatic side chain)
    • Promazine (CAS #: 58-40-2, Phenothiazine with aliphatic side chain)
    • Triflupromazine (CAS #: 146-54-3, Phenothiazine with aliphatic side chain)
    • Methotrimeprazine (CAS #: 60-99-1, Phenothiazine with aliphatic side chain)
    • Thioridazine (CAS #: 50-52-2, Phenothiazine with piperidine side chain)
    • Mesoridazine (CAS #: 5588-33-0, Phenothiazine with piperidine side chain)
    • Acetophenazine (CAS #:2751-68-0, Phenothiazine with piperazine side chain)
    • Perphenazine (CAS #: 58-39-9, Phenothiazine with piperazine side chain)
    • Trifluoperazine (CAS #: 117-89-5, Phenothiazine with piperazine side chain)
    • Fluphenazine (CAS #: 69-23-8, Phenothiazine with piperazine side chain)
    • Prochlorperazine (CAS #: 58-38-8, Phenothiazine with piperazine side chain)
    • Chlorprothixene (CAS #: 113-59-7 Thioxanthene)
    • Thiothixene (CAS #: 22189-31-7, Thioxanthene)
    • Haloperidol (CAS #: 52-86-8, Phenylbutylpiperadine)
    • Pimozide (CAS #: 2062-78-4, Phenylbutylpiperadine)
    • Loxapine (CAS #: 1977-10-2, Dibenzoxazepine)
    • Molindone (CAS #: 7416-34-4, Dihydroindolone)
  • Atypical Antipsychotics
    • Clozapine (CAS #: 5786-21-0, Dibenzoxazepine)
    • Olanzapine (CAS #: 132539-06-1, Dibenzoxazepine)
    • Quetiapine (CAS #: 111974-69-7, Dibenzoxazepine)
    • Ziprasidone (CAS #: 138982-67-9, Benzisoxazole)
    • Risperidone (CAS #: 106266-06-2, Benzisoxazole)
  • Partial dopamine agonists
    • Aripiprazole (CAS #: 129722-12-9, Dihydroquinolinone)
  • Lithium carbonate

Chlorpromazine is the first antipsychotic agent. It is also used as an antiemetic and tranquilizer in the treatment of presurgical apprehension, manic phase of bipolar disorder, intractable hiccups, acute intermittent porphyria, and tetanus, and for the management of severe behavior disorders in children. The chemical name is 2-chloro-N,N-dimethyl-10H- Phenothiazine- 10-propanamine.

SALES SPECIFICATION (HYDROCHLORIDE)

BP/USP/CP

APPEARANCE

 white to off-white crystalline powder

IDENTITY

pass

ASSAY

98.0 - 102.0%

LOSS ON DRYING

1.0% max

RESIDUE ON IGNITION

0.5% max

VORATILE IMPURITY

pass

HEAVY METALS

20 ppm max
TRANSPORTATION
PACKING
25kgs in  Fiber drum
HAZARD CLASS 6.1 (Packing Group: III)
UN NO. 2811
PRICE

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